Michael G. Chavez
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Michael G. Chavez has a total of 25 co-authors. Here are the top co-authors by number of shared publications:
- Abdulvasey Mohammed
Department of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94304, USA
1 shared publication - Anca M. Pasca
Stanford University
1 shared publication - Andrew J. Gentles
Stanford University
1 shared publication - Benjamin D. Solomon
Division of Allergy and Immunology, Department of Pediatrics, School of Medicine, Stanford University, Palo Alto, CA, USA
1 shared publication - Casey A. Gifford
Department of Genetics, Stanford University, Stanford, USA
1 shared publication - Christine Yiwen Yeh
Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, USA
1 shared publication
Latest Publications
- 2 May 2025
- Published by American Association for the Advancement of Science (AAAS) in Science Immunology
- Vol. 10 (107) , eado4720
Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development
Advances in genomics have redefined our understanding of thymic epithelial heterogeneity and architecture, yet signals driving thymic epithelial differentiation remain incompletely understood. Here, we elucidated pathways instructing human thymic epithelial cell development in the context of other anterior foregut–derived organs. Activation of interferon response gene regulatory networks distinguished epithelial cells of the thymus from those of other anterior foregut–derived organs. Thymic cortex and medulla epithelia displayed distinctive interferon-responsive signatures defined by lineage-specific chromatin accessibility. We explored the effects of type I and II interferons on thymic epithelial progenitor differentiation from induced pluripotent stem cells. Type II interferon was essential for expressing proteasome and antigen-presenting molecules, whereas type I or II interferons were essential for inducing different cytokines in thymic epithelial progenitor cells. Our findings suggest that interferons are critical to cortical and medullary thymic epithelial cell differentiation.
- 2 May 2025
- Published by American Association for the Advancement of Science (AAAS) in Science Immunology
- Vol. 10 (107) , eado4720
Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development
Advances in genomics have redefined our understanding of thymic epithelial heterogeneity and architecture, yet signals driving thymic epithelial differentiation remain incompletely understood. Here, we elucidated pathways instructing human thymic epithelial cell development in the context of other anterior foregut–derived organs. Activation of interferon response gene regulatory networks distinguished epithelial cells of the thymus from those of other anterior foregut–derived organs. Thymic cortex and medulla epithelia displayed distinctive interferon-responsive signatures defined by lineage-specific chromatin accessibility. We explored the effects of type I and II interferons on thymic epithelial progenitor differentiation from induced pluripotent stem cells. Type II interferon was essential for expressing proteasome and antigen-presenting molecules, whereas type I or II interferons were essential for inducing different cytokines in thymic epithelial progenitor cells. Our findings suggest that interferons are critical to cortical and medullary thymic epithelial cell differentiation.