Lirong Shen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Lirong Shen has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Hui Chen
College of Food Science and Engineering, JiangXi Agricultural University, Nanchang 330045, China
1 shared publication - Kehui Ouyang
College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China
1 shared publication - Lingli Chen
College of Food Science and Engineering, JiangXi Agricultural University, Nanchang 330045, China
1 shared publication - Suyun Lin
College of Food Science and Engineering, JiangXi Agricultural University, Nanchang 330045, China
1 shared publication - Wenjun Wang
College of Food Science and Engineering, JiangXi Agricultural University, Nanchang 330045, China
1 shared publication - Wenya Meng
Jiangxi Key Laboratory of Natural Products and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China
1 shared publication
Latest Publications
- Open Access
- 7 May 2025
- Published by MDPI AG in Applied Sciences
- Vol. 15 (9) , 5177
Chimonanthus nitens Oliv. Leaf Flavonoids Exert Anti-Inflammatory Effects Through TLR4 Receptor Affecting NF-κB/MAPK Signaling Pathway
Chimonanthus nitens Oliv. leaves (COL), a commonly used traditional Chinese medicine, are rich in a variety of bioactive components, with flavonoids being one of the most abundant. In the current study, RAW264.7 macrophages were induced by lipopolysaccharide (LPS) and treated with COL flavonoids (COLFs). The results demonstrated that COLFs could inhibit the release of nitric oxide (NO) and related inflammatory factors in macrophages. RNA sequencing (RNA-seq) analysis revealed 627 differentially expressed genes (DEGs) in the COLF group, which were further analyzed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. We found that genes involved in biological processes in the LPS and COLF groups were significantly regulated, as indicated by the GO enrichment analysis. The NF-κB signaling pathway was identified through KEGG enrichment analysis for further exploration of the mechanism by which COLFs affect macrophages. Additionally, Western blotting analysis indicated that COLFs could influence the activity of the NF-κB/MAPK signaling pathway via the TLR4 receptor, thereby modulating its anti-inflammatory function. Overall, our results reveal a novel role for COLFs as natural inflammation regulators and provide a theoretical and molecular basis for their development and utilization.
- 7 May 2025
- Published by MDPI AG in Applied Sciences
- Vol. 15 (9) , 5177
Open AccessChimonanthus nitens Oliv. Leaf Flavonoids Exert Anti-Inflammatory Effects Through TLR4 Receptor Affecting NF-κB/MAPK Signaling Pathway
Chimonanthus nitens Oliv. leaves (COL), a commonly used traditional Chinese medicine, are rich in a variety of bioactive components, with flavonoids being one of the most abundant. In the current study, RAW264.7 macrophages were induced by lipopolysaccharide (LPS) and treated with COL flavonoids (COLFs). The results demonstrated that COLFs could inhibit the release of nitric oxide (NO) and related inflammatory factors in macrophages. RNA sequencing (RNA-seq) analysis revealed 627 differentially expressed genes (DEGs) in the COLF group, which were further analyzed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. We found that genes involved in biological processes in the LPS and COLF groups were significantly regulated, as indicated by the GO enrichment analysis. The NF-κB signaling pathway was identified through KEGG enrichment analysis for further exploration of the mechanism by which COLFs affect macrophages. Additionally, Western blotting analysis indicated that COLFs could influence the activity of the NF-κB/MAPK signaling pathway via the TLR4 receptor, thereby modulating its anti-inflammatory function. Overall, our results reveal a novel role for COLFs as natural inflammation regulators and provide a theoretical and molecular basis for their development and utilization.