Emily Stein
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Emily Stein has a total of 17 co-authors. Here are the top co-authors by number of shared publications:
- Ariana Arce
Department of Molecular Biology, UT Southwestern Medical Center, Dallas, Texas
12 shared publications - Bret M. Evers
Department of Pathology, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA
12 shared publications - Cheryl Lewis
Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas
12 shared publications - Chul Ahn
Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, Texas
12 shared publications - Esra A. Akbay
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
12 shared publications - Ignacio Ivan Wistuba
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
12 shared publications
Latest Publications
- Open Access
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Supplementary Figure 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 3 shows the effect of ISR pathway activation on dendritic cells and T cells.
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Figure 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 3 shows the effect of ISR pathway activation on dendritic cells and T cells.
- Open Access
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Supplementary Table 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 4 shows the clinicopathological characteristics of surgically resected primary NSCLC patients included in this study.
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Table 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 4 shows the clinicopathological characteristics of surgically resected primary NSCLC patients included in this study.
- Open Access
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Supplementary Figure 5 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 5 shows the effect of ISR pathway inhibition on immune cell populations in vivo.
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Figure 5 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 5 shows the effect of ISR pathway inhibition on immune cell populations in vivo.
- Open Access
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Supplementary Figure 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 2 shows the effect of ISR pathway activation on protein and mRNA stability, and translation.
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Figure 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 2 shows the effect of ISR pathway activation on protein and mRNA stability, and translation.
- Open Access
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Supplementary Table 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 2 shows the primers used in this study.
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Table 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 2 shows the primers used in this study.
- Open Access
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Supplementary Figure 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 4 shows the effect of ISR pathway inhibition in vitro and in vivo.
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Figure 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 4 shows the effect of ISR pathway inhibition in vitro and in vivo.
- Open Access
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Data from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
The integrated stress response (ISR) is an adaptive pathway hijacked by cancer cells to survive cellular stresses in the tumor microenvironment. ISR activation potently induces PD-L1, leading to suppression of antitumor immunity. In this study, we sought to uncover additional immune checkpoint proteins regulated by the ISR to elucidate mechanisms of tumor immune escape. The ISR coordinately induced cluster of differentiation 155 (CD155) and PD-L1, enhancing translation of both immune checkpoint proteins through bypass of inhibitory upstream open reading frames in their 5′ untranslated regions. Analysis of primary human lung tumors identified a significant correlation between expression of PD-L1 and CD155. ISR activation accelerated tumorigenesis and inhibited T-cell function, which could be overcome by combining PD-1 and TIGIT blockade with the ISR inhibitor ISRIB. This study uncovers a mechanism by which two immune checkpoint proteins are coordinately regulated and suggests a therapeutic strategy for patients with lung cancer.Significance:The integrated stress response represents a targetable axis to improve the efficacy of immunotherapy in lung cancer by inhibiting the coordinated translational regulation of the PD-L1/PD-1 and CD155/TIGIT immune checkpoint pathways.
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Open AccessData from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
The integrated stress response (ISR) is an adaptive pathway hijacked by cancer cells to survive cellular stresses in the tumor microenvironment. ISR activation potently induces PD-L1, leading to suppression of antitumor immunity. In this study, we sought to uncover additional immune checkpoint proteins regulated by the ISR to elucidate mechanisms of tumor immune escape. The ISR coordinately induced cluster of differentiation 155 (CD155) and PD-L1, enhancing translation of both immune checkpoint proteins through bypass of inhibitory upstream open reading frames in their 5′ untranslated regions. Analysis of primary human lung tumors identified a significant correlation between expression of PD-L1 and CD155. ISR activation accelerated tumorigenesis and inhibited T-cell function, which could be overcome by combining PD-1 and TIGIT blockade with the ISR inhibitor ISRIB. This study uncovers a mechanism by which two immune checkpoint proteins are coordinately regulated and suggests a therapeutic strategy for patients with lung cancer.Significance:The integrated stress response represents a targetable axis to improve the efficacy of immunotherapy in lung cancer by inhibiting the coordinated translational regulation of the PD-L1/PD-1 and CD155/TIGIT immune checkpoint pathways.
- Open Access
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Supplementary Table 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 1 shows the chemicals used in this study.
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Table 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 1 shows the chemicals used in this study.
- Open Access
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Supplementary Table 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 3 shows the antibodies used in this study.
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Table 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 3 shows the antibodies used in this study.
- Open Access
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Supplementary Figure 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 1 shows the effect of ISR pathway activation on multiple immune checkpoint proteins
- 15 July 2025
- Published by American Association for Cancer Research (AACR)
Open AccessSupplementary Figure 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 1 shows the effect of ISR pathway activation on multiple immune checkpoint proteins