Brooke Roeges
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Brooke Roeges has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
- Abdur Rahim Badsha
Division of Science and Mathematics, Mayville State University, Mayville, ND 58257, USA
1 shared publication - Abulquasem Rayat Hossain
Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58108, USA
1 shared publication - Dorsa Fereydoonpour
Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58108, USA
1 shared publication - George Davisson
Division of Science and Mathematics, Mayville State University, Mayville, ND 58257, USA
1 shared publication - Hayle Boechler
Mayville State University, USA
1 shared publication - Kaydee Koistinen
Division of Science and Mathematics, Mayville State University, Mayville, ND 58257, USA
1 shared publication
Latest Publications
- Open Access
- 15 May 2025
- Published by MDPI AG in Preprints.org
Wheat Bran Polymer Scaffolds: Supporting Triple-Negative Breast Cancer Cell Growth and Development
Arabinoxylans (AX) are functional biopolymers, the main non-starch polysaccharides in cereals and other plants. AX is composed of xylose and arabinose, and the ester-linkage of ferulic acid to arabinose confers its bioactive properties. The backbone of AX resembles that of glycosaminoglycans, a major component of the human extracellular matrix. This study explores the potential of wheat bran AX-based scaffolds as a novel platform for the growth and development of triple-negative breast cancer (TNBC) cells, an aggressive form of breast cancer. Importantly, patients face the worst prognosis due to the stemness of the TNBC cells and the formation of hypoxic cell clumps. Wheat bran constitutes 15%- 25% of the byproducts after milling and adds limited economic value. We have extracted AX from wheat bran (WBAX) and developed soft scaffolds with Na-alginate. The scaffolds were seeded with the triple-negative breast cancer cell line MDA-MB-231. Over 21 days, cell growth and development, cell migration within the hydrogels, maintenance of cell stemness, and the formation of hypoxic regions within cell clumps were observed. These findings suggest that WBAX-based scaffolds provide a conducive environment for TNBC cell proliferation and development, offering a promising avenue for further research into cancer cell biology and potential therapeutic applications.
- 15 May 2025
- Published by MDPI AG in Preprints.org
Open AccessWheat Bran Polymer Scaffolds: Supporting Triple-Negative Breast Cancer Cell Growth and Development
Arabinoxylans (AX) are functional biopolymers, the main non-starch polysaccharides in cereals and other plants. AX is composed of xylose and arabinose, and the ester-linkage of ferulic acid to arabinose confers its bioactive properties. The backbone of AX resembles that of glycosaminoglycans, a major component of the human extracellular matrix. This study explores the potential of wheat bran AX-based scaffolds as a novel platform for the growth and development of triple-negative breast cancer (TNBC) cells, an aggressive form of breast cancer. Importantly, patients face the worst prognosis due to the stemness of the TNBC cells and the formation of hypoxic cell clumps. Wheat bran constitutes 15%- 25% of the byproducts after milling and adds limited economic value. We have extracted AX from wheat bran (WBAX) and developed soft scaffolds with Na-alginate. The scaffolds were seeded with the triple-negative breast cancer cell line MDA-MB-231. Over 21 days, cell growth and development, cell migration within the hydrogels, maintenance of cell stemness, and the formation of hypoxic regions within cell clumps were observed. These findings suggest that WBAX-based scaffolds provide a conducive environment for TNBC cell proliferation and development, offering a promising avenue for further research into cancer cell biology and potential therapeutic applications.