Hongyu Du
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Hongyu Du has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
Chen Xie
Gannan Medical College: Gannan Medical University
1 shared publicationJiayi Yuan
Gannan Medical College: Gannan Medical University
1 shared publicationJinguo Cao
Gannan Medical College: Gannan Medical University
1 shared publication- Wei Li
School of Rehabilitation Medicine, Gannan Medical University
1 shared publication Yiqin Yuan
Gannan Medical College: Gannan Medical University
1 shared publicationYun Luo
Gannan Medical College: Gannan Medical University
1 shared publication
Latest Publications
- Open Access
Efficacy and safety of stem cell therapy for diabetic kidney disease: a systematic review and meta-analysis
Background/Objectives: Animal studies have demonstrated the ability of stem cell therapy (SCT) to treat diabetic kidney disease (DKD). However, the safety and efficacy of SCT in patients with DKD remain unclear. This systematic review and meta-analysis aimed to investigate the safety and efficacy of SCT in patients with DKD. Methods: A comprehensive and systematic literature search was conducted using PubMed, EMBASE, Cochrane Library, and Web of Science to identify articles on SCT for DKD published up to March 2024. RevMan V.5.4 software was used for statistical analysis. Results: We identified four studies that included 90 participants, 53 (58%) of whom underwent SCT. SCT improved estimated glomerular filtration rate (eGFR) (mean difference [MD] = 0.41, 95% confidence interval [CI]: 0.08–0.74; p < 0.05), serum creatinine (SCr) reduction (standardized MD = -0.65, 95%CI: -1.19 to -0.1, p < 0.05), and microalbuminuria (MAU) (MD = -32.10, 95% CI: -55.26–8.94; p < 0.05) compared to the control group, but did not improve urine microalbumin/creatinine ratio (UACR) (MD = -63.36, 95% CI: 194.52–67.79, p = 0.56) or blood sugar (MD = 0.49, 95% CI: 4.16–2.01, p = 0.49). In addition, the incidence of adverse events was significantly high in both groups (risk ratio = 0.93; 95% CI: 0.74–1.17; p = 0.54); there was no significant difference regarding I 2 = 0%). Conclusions: SCT can safely and effectively improve eGFR and SCr levels by lowering the MAU but cannot improve UACR and blood sugar levels.
Open AccessEfficacy and safety of stem cell therapy for diabetic kidney disease: a systematic review and meta-analysis
Background/Objectives: Animal studies have demonstrated the ability of stem cell therapy (SCT) to treat diabetic kidney disease (DKD). However, the safety and efficacy of SCT in patients with DKD remain unclear. This systematic review and meta-analysis aimed to investigate the safety and efficacy of SCT in patients with DKD. Methods: A comprehensive and systematic literature search was conducted using PubMed, EMBASE, Cochrane Library, and Web of Science to identify articles on SCT for DKD published up to March 2024. RevMan V.5.4 software was used for statistical analysis. Results: We identified four studies that included 90 participants, 53 (58%) of whom underwent SCT. SCT improved estimated glomerular filtration rate (eGFR) (mean difference [MD] = 0.41, 95% confidence interval [CI]: 0.08–0.74; p < 0.05), serum creatinine (SCr) reduction (standardized MD = -0.65, 95%CI: -1.19 to -0.1, p < 0.05), and microalbuminuria (MAU) (MD = -32.10, 95% CI: -55.26–8.94; p < 0.05) compared to the control group, but did not improve urine microalbumin/creatinine ratio (UACR) (MD = -63.36, 95% CI: 194.52–67.79, p = 0.56) or blood sugar (MD = 0.49, 95% CI: 4.16–2.01, p = 0.49). In addition, the incidence of adverse events was significantly high in both groups (risk ratio = 0.93; 95% CI: 0.74–1.17; p = 0.54); there was no significant difference regarding I 2 = 0%). Conclusions: SCT can safely and effectively improve eGFR and SCr levels by lowering the MAU but cannot improve UACR and blood sugar levels.