Zhuoyuan He
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Zhuoyuan He has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Chuanying Pan
College of Animal Science and Technology, Northwest A&F University, Yangling, China
1 shared publication - Chuzhao Lei
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China
1 shared publication - Enhui Jiang
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
1 shared publication - Fugui Jiang
Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China
1 shared publication - Hongyang Wang
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
1 shared publication - Leijing Zhu
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
1 shared publication
Latest Publications
- Open Access
- 6 June 2025
- Published by MDPI AG in Agriculture
- Vol. 15 (12) , 1240
Detection of Copy Number Variations from HIF1A and HIF2A Gene as Genetic Determinants of Bovine Carcass Traits
The beef cattle industry has seen rapid expansion, necessitating the optimization of slaughter traits for enhanced economic benefits. Copy number variation (CNV) has emerged as a pivotal molecular marker in marker-assisted selection (MAS) for genetic improvement in livestock. In this study, we focused on CNVs within the HIF1A and HIF2A genes, which play crucial roles in hypoxic signaling and energy metabolism. Four CNVs were identified in the bovine HIF1A gene and three in HIF2A using the AAOD database. In Gaoqing Black cattle (GQB), the distribution of CNVs for both genes was investigated, revealing predominantly median copy numbers. Association analysis showed a significant relation between CNVs in HIF1A and carcass traits such as cervical vertebrae (CNV1), initial weight and beef diaphragm (CNV2), slaughter weight and chuck (CNV3), and femur and chuck (CNV4) (p < 0.05 or p < 0.01). Similarly, CNVs in HIF2A are associated with traits like beef diaphragm, beef knuckle bone, and beef tendon (CNV1), longissimus dorsi width and beef diaphragm (CNV2), and slaughter weight and limb weights (CNV3) (p < 0.05 or p < 0.01). These findings provide insights into the potential influence of CNVs in HIF1A and HIF2A on carcass traits in Gaoqing Black cattle, offering a theoretical basis for genetic improvement in beef cattle breeding.
- 6 June 2025
- Published by MDPI AG in Agriculture
- Vol. 15 (12) , 1240
Open AccessDetection of Copy Number Variations from HIF1A and HIF2A Gene as Genetic Determinants of Bovine Carcass Traits
The beef cattle industry has seen rapid expansion, necessitating the optimization of slaughter traits for enhanced economic benefits. Copy number variation (CNV) has emerged as a pivotal molecular marker in marker-assisted selection (MAS) for genetic improvement in livestock. In this study, we focused on CNVs within the HIF1A and HIF2A genes, which play crucial roles in hypoxic signaling and energy metabolism. Four CNVs were identified in the bovine HIF1A gene and three in HIF2A using the AAOD database. In Gaoqing Black cattle (GQB), the distribution of CNVs for both genes was investigated, revealing predominantly median copy numbers. Association analysis showed a significant relation between CNVs in HIF1A and carcass traits such as cervical vertebrae (CNV1), initial weight and beef diaphragm (CNV2), slaughter weight and chuck (CNV3), and femur and chuck (CNV4) (p < 0.05 or p < 0.01). Similarly, CNVs in HIF2A are associated with traits like beef diaphragm, beef knuckle bone, and beef tendon (CNV1), longissimus dorsi width and beef diaphragm (CNV2), and slaughter weight and limb weights (CNV3) (p < 0.05 or p < 0.01). These findings provide insights into the potential influence of CNVs in HIF1A and HIF2A on carcass traits in Gaoqing Black cattle, offering a theoretical basis for genetic improvement in beef cattle breeding.