Chantal Francois
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Chantal Francois has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Andreas Heuer
Behavioural Neuroscience Laboratory , Department of Experimental Medical Science , Lund University , Lund , Sweden , lu.se
4 shared publications - Carine Karachi
Sorbonne Université, INSERM, CNRS, Paris Brain Institute Institut du Cerveau, Paris, France
4 shared publications - Julia Staryk
Lund University, Department of Clinical Sciences Lund (IKVL), Neurology Unit, Molecular Neuroanatomy Lab, Sölvegatan 19, 223 62 Lund, Sweden
4 shared publications - Marie Biviano Rosenkilde
Gubra, Hørsholm Kongevej 11B, 2970 Hørsholm, Denmark
4 shared publications - Sylvie Dumas
Oramacell, 75006 Paris, France
4 shared publications - Urmas Roostalu
Gubra ApS Hørsholm Denmark
4 shared publications
Latest Publications
- 23 October 2026
- Published by EMBL-EBI
Comparative molecular mapping reveals molecular gradients and spatially organized populations in the subthalamic and para-subthalamic regions
BioStudies – one package for all the data supporting a study
- 23 October 2026
- Published by EMBL-EBI
Comparative molecular mapping reveals molecular gradients and spatially organized populations in the subthalamic and para-subthalamic regions
BioStudies – one package for all the data supporting a study
- 23 October 2026
- Published by EMBL-EBI
Comparative molecular mapping reveals molecular gradients and spatially organized populations in the subthalamic and para-subthalamic regions
BioStudies – one package for all the data supporting a study
- 23 October 2026
- Published by EMBL-EBI
Comparative molecular mapping reveals molecular gradients and spatially organized populations in the subthalamic and para-subthalamic regions
BioStudies – one package for all the data supporting a study
- 22 October 2026
- Published by EMBL-EBI
Comparative molecular mapping reveals molecular gradients and spatially organized populations in the subthalamic and para-subthalamic regions
BioStudies – one package for all the data supporting a study
- 22 October 2026
- Published by EMBL-EBI
Comparative molecular mapping reveals molecular gradients and spatially organized populations in the subthalamic and para-subthalamic regions
BioStudies – one package for all the data supporting a study
- Open Access
Comparative molecular mapping reveals molecular gradients and spatially organized populations in the subthalamic and para-subthalamic regions
The subthalamic nucleus (STN) is a major target for deep brain stimulation (DBS) in Parkinson’s disease (PD), yet its molecular organization and relationship to the adjacent para-subthalamic nucleus (pSTN) remain incompletely defined. Here, we performed comparative molecular mapping of the STN and pSTN in mouse and macaque, complemented by a human tissue sample, three-dimensional imaging, and publicly available spatial transcriptomic datasets. The STN showed a largely conserved molecular framework across species with gradients across rostrocaudal and dorsolateral axes. However, HTR2C was found enriched in the ventral STN of macaque and human tissue samples, while broadly distributed across the mouse STN. HTR2C showed opposite gradient of PVALB . In the mouse STN, Nts expression revealed an additional mediolateral gradient. Publicly available transcriptomic datasets showed concordant expression patterns. In both species, TAC1 characterized the canonical pSTN but also an extended population reaching dorsally along the medial aspect of the STN. TAC1 -positive cells were thus found in the region traversed by tyrosine hydroxylase-positive fibers of the medial forebrain bundle (MFB). Together, these findings reveal a spatially heterogeneous, multiaxial molecular organization of the STN and a spatially complex molecular organization of its neighboring brain areas, refining the molecular and anatomical framework of the subthalamic region.
Open AccessComparative molecular mapping reveals molecular gradients and spatially organized populations in the subthalamic and para-subthalamic regions
The subthalamic nucleus (STN) is a major target for deep brain stimulation (DBS) in Parkinson’s disease (PD), yet its molecular organization and relationship to the adjacent para-subthalamic nucleus (pSTN) remain incompletely defined. Here, we performed comparative molecular mapping of the STN and pSTN in mouse and macaque, complemented by a human tissue sample, three-dimensional imaging, and publicly available spatial transcriptomic datasets. The STN showed a largely conserved molecular framework across species with gradients across rostrocaudal and dorsolateral axes. However, HTR2C was found enriched in the ventral STN of macaque and human tissue samples, while broadly distributed across the mouse STN. HTR2C showed opposite gradient of PVALB . In the mouse STN, Nts expression revealed an additional mediolateral gradient. Publicly available transcriptomic datasets showed concordant expression patterns. In both species, TAC1 characterized the canonical pSTN but also an extended population reaching dorsally along the medial aspect of the STN. TAC1 -positive cells were thus found in the region traversed by tyrosine hydroxylase-positive fibers of the medial forebrain bundle (MFB). Together, these findings reveal a spatially heterogeneous, multiaxial molecular organization of the STN and a spatially complex molecular organization of its neighboring brain areas, refining the molecular and anatomical framework of the subthalamic region.