Shihao Wang

The monocyte-to-high-density lipoprotein cholesterol ratio (MHR), an indicator of inflammation and lipid metabolism, has demonstrated significant clinical potential. The study aims to investigate the association between the MHR and total testosterone (TT) levels, as well as testosterone deficiency (TD) risk, utilizing data from the NHANES. We analyzed data from 6,194 adult men from NHANES 2011-2016. Multivariate linear and logistic regression analyses were conducted to evaluate associations of MHR with TT levels and TD risk, respectively. Restricted cubic spline (RCS) analyses and subgroup analyses further assessed the robustness of our findings. In the fully adjusted model, each unit increase in log-transformed MHR was associated with a decrease in TT (β = -47.91, 95% CI: -62.39, -33.43, P < 0.001) and an increase in TD risk (OR = 1.81, 95% CI: 1.46, 2.24, P < 0.001). RCS analysis confirmed a linear relationship, and the findings were consistent across subgroup analyses. This study showed that in the United States (US) adult men, a high MHR is linked to low TT levels and a higher TD risk. These findings suggest MHR could be a useful marker for early detection of low testosterone and TD risk, warranting further prospective research for confirmation.

Background: Benign prostatic hyperplasia (BPH), as a cause of various lower urinary tract symptoms (LUTS), can improve patients’ quality of life when effectively controlled. To elaborate on the effect of dietary calcium intake on BPH, we investigated the association between dietary calcium intake and the risk of BPH using data from the National Health and Nutrition Examination Survey (NHANES). Methods: Data from the NHANES conducted from 2003 to 2008 were utilized. BPH was identified through self-reported questionnaires, and dietary calcium intake was calculated based on the mean of two 24-hour dietary recall interviews. Multivariable logistic regression analyses were performed to assess the association, supplemented by restricted cubic spline analysis and subgroup analyses. Results: A total of 590 males aged 40 years and older were included in the study, of whom 138 had BPH. After adjusting for all covariates, a higher dietary calcium intake was associated with an increased risk of BPH [odds ratio (OR), 1.05; 95% confidence interval (CI): 1.01–1.09; P=0.04], and those without hypertension. Conclusions: The study found a positive association between dietary calcium intake and the risk of BPH among U.S. men aged 40 years and older. High calcium intake may be associated with the occurrence of BPH, particularly in older individuals. These findings underscore the importance of monitoring dietary calcium intake as part of BPH prevention strategies.