Yan Chen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Yan Chen has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Gaohua Han
Dalian Medical University, China
1 shared publication Guiyuan Liu
Department of General Surgery, The Affiliated Taizhou people’s Hospital of Nanjing Medical University, Taizhou, China
1 shared publication- Qing Guo
The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
1 shared publication Wei Yuan
Department of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, China
1 shared publicationWei Zhang
Department of Oncology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, China
1 shared publication
Latest Publications
- Open Access
- 1 July 2025
- Published by Springer Nature in BMC Cancer
- Vol. 25 (1) , 1-5
Urinary paranitrophenol levels and risk of cancer mortality: evidence from NHANES
Paranitrophenol, a metabolite of organophosphate insecticides, was associated with various adverse health outcomes. However, the association of Paranitrophenol with all-cause and cancer mortality in adults remains unclear. A total of 3,362 participants (1680 male) were included from the National Health and Nutrition Examination Surveys (NHANES). Urinary Paranitrophenol was measured using ultra-high-performance LC-MS/MS. Mortality status and causes were obtained from National Death Index. Cox proportional hazards regression analysis was performed to explore the associations between Paranitrophenol and all-cause and cancer mortality, respectively. After a follow-up of 22.75 thousand person-years, there were 297 deaths from all causes and 69 deaths from cancer. Comparing with the lowest quartile, the highest quartile was not associated with all-cause mortality in the neither univariate model nor adjusted model. In terms of cancer mortality, the hazard ratios and 95% confidence interval of the highest quartile is 0.44 (0.21–0.93) in the univariate model, 0.40 (0.18–0.86) in the partly-adjusted model, and 0.40 (0.18–0.88) in the fully-adjusted model. Higher urinary Paranitrophenol levels were associated with a decreased risk of cancer mortality. This association remained independent of demographics, lifestyle factors, and comorbidities.
- 1 July 2025
- Published by Springer Nature in BMC Cancer
- Vol. 25 (1) , 1-5
Open AccessUrinary paranitrophenol levels and risk of cancer mortality: evidence from NHANES
Paranitrophenol, a metabolite of organophosphate insecticides, was associated with various adverse health outcomes. However, the association of Paranitrophenol with all-cause and cancer mortality in adults remains unclear. A total of 3,362 participants (1680 male) were included from the National Health and Nutrition Examination Surveys (NHANES). Urinary Paranitrophenol was measured using ultra-high-performance LC-MS/MS. Mortality status and causes were obtained from National Death Index. Cox proportional hazards regression analysis was performed to explore the associations between Paranitrophenol and all-cause and cancer mortality, respectively. After a follow-up of 22.75 thousand person-years, there were 297 deaths from all causes and 69 deaths from cancer. Comparing with the lowest quartile, the highest quartile was not associated with all-cause mortality in the neither univariate model nor adjusted model. In terms of cancer mortality, the hazard ratios and 95% confidence interval of the highest quartile is 0.44 (0.21–0.93) in the univariate model, 0.40 (0.18–0.86) in the partly-adjusted model, and 0.40 (0.18–0.88) in the fully-adjusted model. Higher urinary Paranitrophenol levels were associated with a decreased risk of cancer mortality. This association remained independent of demographics, lifestyle factors, and comorbidities.