Zilin Zhao

This study aimed to systematically characterize the global research landscape, collaboration patterns, knowledge structure, and emerging hotspots of glucagon-like peptide-1 receptor agonists in neurodegenerative diseases using bibliometric methods. Publications related to glucagon-like peptide-1 receptor agonists and neurodegenerative diseases were retrieved from the Web of Science Core Collection from 2006 to 2025. Only English-language articles and reviews were included. Bibliometric analyses were performed using Bibliometrix, VOSviewer, and CiteSpace to evaluate annual publication trends, country and institutional contributions, author collaborations, journal distribution, citation structures, keyword co-occurrence, thematic evolution, and citation bursts. A Scopus-based sensitivity analysis was conducted to assess the robustness of the main bibliometric findings. A total of 1,202 publications were included, with annual output increasing from 2 in 2006 to 241 in 2025, particularly after 2020. China, the USA, and England were the leading contributors and major collaboration hubs. Shanxi Medical University, Lancaster University, and the National Institute on Aging were among the most productive institutions, while major journals included International Journal of Molecular Sciences, Neuropharmacology, European Journal of Pharmacology, Frontiers in Endocrinology, Frontiers in Pharmacology, and Journal of Alzheimer’s Disease. Keyword and citation analyses indicated a thematic shift from exendin-4, Alzheimer’s disease, Parkinson’s disease, and neuroprotection toward semaglutide, neuroinflammation, cognitive impairment, clinical efficacy, evidence synthesis, and combination therapy. Research on glucagon-like peptide-1 receptor agonists in neurodegenerative diseases has expanded rapidly over the past two decades. Current bibliometric evidence suggests that this field has evolved from preclinical exploration toward broader translational and clinical research, with increasing attention to neuroinflammation, metabolic dysfunction, cognitive outcomes, and newer incretin-based therapies. However, the therapeutic implications of glucagon-like peptide-1 receptor agonists for neurodegenerative diseases remain to be further validated by high-quality mechanistic studies and well-designed clinical trials.

Objectives To conduct a qualitative meta-integration of existing empirical qualitative research on the spiritual experiences and unmet spiritual needs of advanced cancer patients receiving palliative care worldwide, so as to systematically synthesize the core spiritual perceptions, triggering factors of spiritual needs and spiritual coping strategies of this population, and provide evidence-based reference for exploring individualized holistic care oriented to the spiritual needs of advanced cancer patients and building a palliative care support system based on spiritual care. Methods Qualitative studies on spiritual needs of patients with advanced palliative care for cancer were searched in PubMed, Web of Science, ProQuest, Wanfang database, CNKI and VIP database, and the search time was from the establishment of the database to January 2024. The quality of the literature was evaluated using the Quality Evaluation Criteria of the Center for Qualitative Research in Evidence-based Health Care (Joanna Briggs Institute, Australia) (2016), and the results were integrated by Meta integration method. Results A total of 17 literatures were included, and 138 main research results were extracted. The similar results were summarized into 13 new categories and integrated into 3 results: (1) Hope, religion and wisdom are the spiritual understanding of patients in palliative care; (2) The physical and mental burden, the challenge of family care and social relationship, and the conflict of self-role are the possible factors that trigger the spiritual needs of cancer patients; (3) Self-awareness, resilience and reconstruction of interpersonal relationships are the spiritual responses to palliative care for cancer patients. Conclusion Patients with advanced cancer in palliative care have heavy physical and mental burden and long for love and support. Attention should be paid to the real inner experience and spiritual needs of cancer patients in palliative care, and individualized holistic care should be provided to promote patients to recover or maintain physical, mental, social and spiritual health.

Background: Climate change is a critical 21st-century global challenge affecting the environment, public health, and social well-being. Climate anxiety is increasingly prevalent among nursing students, who bear a dual burden of personal psychological stress and professional responsibility for addressing climate-related health consequences. However, synthesized evidence on this topic remains limited. Aims: To comprehensively map the assessment tools, influencing factors, and intervention strategies related to climate anxiety among nursing students, identify key knowledge gaps, and provide evidence-based recommendations for future research and nursing education. Design: Scoping review conducted following the Arksey and O’Malley framework and reported in accordance with the PRISMA extension for Scoping Reviews (PRISMA-ScR) 2020 guidelines. Data sources: Seven major electronic databases (PubMed, Cochrane Library, Embase, CINAHL, Web of Science Core Collection, Scopus, and Medline) were searched from database inception to March 1, 2026. Methods: Literature was screened based on the PCC (Population, Concept, Context) framework, followed by rigorous two-stage independent screening and standardized data charting by two reviewers. Results: Thirteen studies involving a total of 5,096 nursing students were included. All studies were published between 2024 and 2025, with the majority conducted in Turkey ( n = 8), followed by Egypt ( n = 3), Saudi Arabia ( n = 1), and South Korea ( n = 1). Findings confirmed a notable prevalence of climate anxiety among nursing students, shaped by multiple interrelated factors including gender, academic year, climate change awareness, intolerance of uncertainty, environmental literacy, and media exposure. Four validated assessment tools were identified. Two intervention studies (one RCT and one quasi-experimental study) suggested that structured educational programs may help mitigate certain dimensions of climate anxiety. Conclusions: Climate anxiety significantly impacts nursing students’ psychological well-being and professional readiness. Targeted educational initiatives incorporating climate change content and psychological support components are warranted. Future research should address the current geographic and methodological limitations, refine population-specific assessment tools, and rigorously evaluate psychological interventions, including cognitive behavioral approaches. Impact: This review provides practical guidance for nursing educators and healthcare practitioners, effectively strengthening future healthcare professionals’capacity to address climate-related challenges. Public contribution: Although there was no direct public or patient involvement, the review’s findings indirectly benefit the public by informing better care. Future research could integrate nursing student feedback to further refine related designs. Clinical trial number: Not applicable, as this is a scoping review that does not involve clinical trial registration.

Background: Alzheimer’s disease patients often experience cognitive decline during disease progression, impacting their quality of life. Photostimulation therapy, as a non-invasive neuromodulation method, has been increasingly used in the adjunctive management of Alzheimer’s patients in recent years. Despite the increasing number of related studies, a systematic review and comprehensive evaluation are still lacking. Objective: This review systematically summarizes the current application of photostimulation therapy in Alzheimer’s disease patients, outlines its implementation characteristics, outcome indicators, intervention effects and mechanisms of action in cognitive function intervention, and identifies evidence gaps in current research. Methods: Relevant studies were systematically retrieved from PubMed, Web of Science, Cochrane Library, Embase, CINAHL, CNKI, CBM, WanFang Database, and VIP Database from their inception to January 5, 2026. Data from the included literature were extracted and analyzed. Results: A total of 21 studies were included. Photostimulation therapy primarily includes light stimulation, 40 Hz rhythm-related light stimulation, photobiological modulation and their combined therapies, as well as transcatheter intracranial laser therapy. This therapy has potential value in improving cognitive function or delaying cognitive decline and may affect sleep/rhythm and behavioral symptoms. Its potential mechanisms involve neural oscillation modulation, circadian rhythm reconstruction, and improvement of synaptic plasticity. However, existing evidence exhibits significant heterogeneity in study design, sample size, intervention parameters, and outcome indicators. Conclusion: Photostimulation therapy has shown promising potential in cognitive function intervention for Alzheimer’s disease patients, but current evidence is still largely in the exploratory stage. Future research should focus on multi-center, large-sample, and standardized studies to determine the optimal parameter combinations for different stages and scenarios, and to optimize individualized intervention protocols to improve clinical efficacy. Plain Language Summary: Investigates the effectiveness and limitations of photostimulation therapy in improving cognitive function in Alzheimer’s disease patients and summarizes its mechanisms of action. The results show that photostimulation therapy shows promising potential in improving cognitive function in Alzheimer’s patients, and its mechanism of action involves multiple aspects. However, existing evidence exhibits heterogeneity in terms of study design and sample size, necessitating future multi-center, large-sample, and standardized studies. Infographic on photostimulation therapy for Alzheimer’s, covering introduction, literature screening and conclusions.

Objective To systematically review the intervention content and efficacy of auriculotherapy in alleviating cancer-related fatigue symptom clusters, analyze its current application status and existing limitations, and provide references for clinical practice and future research. Methods A scoping review was adopted. Systematic searches were conducted in databases including CNKI, Wanfang, VIP, SinoMed, PubMed, Web of Science, Cochrane Library, Embase, and CINAHL. The search period spanned from the inception of each database to May 15, 2025. Relevant data from the included studies were extracted and analyzed. Results Fourteen studies with a total sample size of 1208 participants were ultimately included. The interventions primarily targeted the pain-fatigue-sleep disturbance symptom cluster and the fatigue-anxiety symptom cluster. Auricular acupressure was the most common intervention, with an average of five to 12 auricular points selected. Shenmen, subcortex, and sympathetic were the top three most frequently used auricular points. The intervention durations ranged from 3 days to 8 weeks, with frequencies of intervention of three to six times per day. The common intervention methods included auricular acupressure, auricular acupuncture, and auricular laser therapy. Conclusion Auriculotherapy is simple to operate, low in cost, and highly safe and was associated with potential benefits in the management of cancer-related fatigue symptom clusters, though intervention protocols varied widely. However, the current intervention protocols are not standardized, and there is a lack of unified symptom cluster assessment tools. Future research should standardize the intervention protocols and optimize the evaluation tools and auricular intervention regimens, so as to further enhance the clinical value of auriculotherapy in the management of cancer-related fatigue symptom clusters.