Alan Aguilar-Aguilar
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Alan Aguilar-Aguilar has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- David M. Aparicio
Chemistry Center, Institute of Sciences, Benemérita Autonomous University of Puebla (BUAP), Building IC-9, Science Complex, City University, Puebla 72570, Mexico
3 shared publications - Joel L. Terán
Centro de Quimica, Instituto de Ciencias, BUAP, Puebla 72570, Mexico
3 shared publications - Jorge Rigoberto Juárez Posadas
Centro de Química, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla City, Mexico, Mexico
3 shared publications - Félix May-Moreno
Chemistry Center, Institute of Sciences, Benemérita Autonomous University of Puebla (BUAP), Building IC-9, Science Complex, City University, Puebla 72570, Mexico
2 shared publications - Ángel Palillero-Cisneros
Chemistry Center, Institute of Sciences, Benemérita Autonomous University of Puebla (BUAP), Building IC-9, Science Complex, City University, Puebla 72570, Mexico
2 shared publications - Alan Carrasco-Carballo
Laboratorio de Elucidación y Síntesis en Química Orgánica, Centro de Química, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla 72570, Mexico
1 shared publication
Latest Publications
- Open Access
Synthesis of (R)-(+)-3-(1-Hydroxyethylidene)-1-(1-phenylethyl)piperidine-2,4-dione, a Novel Tetramic Acid Analog
Herein, starting from (R)-(+)-α-methylbenzylamine, we report an efficient synthesis and full characterization of a new (R)-3-(1-hydroxyethylidene)-1-(1-phenylethyl)piperidine-2,4-dione, a new tetramic acid analog. The key steps involved a non-classical Corey–Chaykovsky intramolecular cyclization reaction to access the corresponding zwitterion, followed by a sequential desulfurization/reduction and condensation procedure. The titled product was obtained in five steps, and the desired product 7 with an overall 58% yield.
Open AccessSynthesis of (R)-(+)-3-(1-Hydroxyethylidene)-1-(1-phenylethyl)piperidine-2,4-dione, a Novel Tetramic Acid Analog
Herein, starting from (R)-(+)-α-methylbenzylamine, we report an efficient synthesis and full characterization of a new (R)-3-(1-hydroxyethylidene)-1-(1-phenylethyl)piperidine-2,4-dione, a new tetramic acid analog. The key steps involved a non-classical Corey–Chaykovsky intramolecular cyclization reaction to access the corresponding zwitterion, followed by a sequential desulfurization/reduction and condensation procedure. The titled product was obtained in five steps, and the desired product 7 with an overall 58% yield.
- Open Access
- 6 April 2026
- Published by MDPI AG in Preprints.org
Synthesis of (R)-(+)-3-(1-hydroxyethylidene)-1-(1-phenylethyl)piperidine-2,4-dione, novel Tetramic Acid Analogue
Herein, starting from (R)-(+)-α-methylbenzylamine, we report an efficient synthesis and full characterization of a new (R)-3-(1-hydroxyethylidene)-1-(1-phenylethyl)piperidine-2,4-dione, a new tetramic acid analogue. The key steps involved a non-classical Corey-Chaykovsky intramolecular cy-clization reaction to access the corresponding zwitterion, followed by a sequential desul-furization/reduction and condensation procedure. The key intermediate was obtained in 5 steps, and the desired product 7 with an overall 58% yield.
- 6 April 2026
- Published by MDPI AG in Preprints.org
Open AccessSynthesis of (R)-(+)-3-(1-hydroxyethylidene)-1-(1-phenylethyl)piperidine-2,4-dione, novel Tetramic Acid Analogue
Herein, starting from (R)-(+)-α-methylbenzylamine, we report an efficient synthesis and full characterization of a new (R)-3-(1-hydroxyethylidene)-1-(1-phenylethyl)piperidine-2,4-dione, a new tetramic acid analogue. The key steps involved a non-classical Corey-Chaykovsky intramolecular cy-clization reaction to access the corresponding zwitterion, followed by a sequential desul-furization/reduction and condensation procedure. The key intermediate was obtained in 5 steps, and the desired product 7 with an overall 58% yield.
- 1 May 2025
- Published by Pleiades Publishing Ltd in Russian Journal of Organic Chemistry
- Vol. 61 (5) , 911-918
Intramolecular Cyclization of Grignard or Blaise Intermediates for the Synthesis of a Chiral Piperidine-2,4-dione Derived from (R)-(‒)-Phenylglycinol
In this work, we describe the synthesis of chiral (R)-(‒)-piperidine-2,4-dione derived from (R)-(‒)-phenylglycinol, a valuable building block for the diastereoselective synthesis of piperidine alkaloids. The key step involves intramolecular cyclization: when the electrophile is an ester, the reaction proceeds via the formation of a Grignard intermediate, whereas when the electrophile is a nitrile, the cyclization follows a Blaise-type mechanism.
- 1 May 2025
- Published by Pleiades Publishing Ltd in Russian Journal of Organic Chemistry
- Vol. 61 (5) , 911-918
Intramolecular Cyclization of Grignard or Blaise Intermediates for the Synthesis of a Chiral Piperidine-2,4-dione Derived from (R)-(‒)-Phenylglycinol
In this work, we describe the synthesis of chiral (R)-(‒)-piperidine-2,4-dione derived from (R)-(‒)-phenylglycinol, a valuable building block for the diastereoselective synthesis of piperidine alkaloids. The key step involves intramolecular cyclization: when the electrophile is an ester, the reaction proceeds via the formation of a Grignard intermediate, whereas when the electrophile is a nitrile, the cyclization follows a Blaise-type mechanism.