Chunbiao Wu

Emerging evidence highlights the pivotal role of KISS1 in cancer metastasis; however, there remains a dearth of pancancer analyses, particularly concerning immunotherapy. Here, we conducted a comprehensive investigation of KISS1 across various cancers, with a specific focus on breast cancer, using TCGA and GTEx datasets. We observed a tissue context‐dependent role function of KISS1 in tumor metastasis, which exhibited suppressive effects in various tumors but promoted the metastatic phenotype in breast cancer. Our study revealed a noteworthy disparity between KISS1 expression at the mRNA and protein levels, indicating potential posttranslational modifications within cancer cells. Moreover, KISS1 is significantly associated with immune cell infiltration and immunosuppressive cells, suggesting its crucial role in modulating tumor immunotherapy. Intriguingly, our investigation also elucidated KISS1’s involvement in promoting breast cancer metastasis, thereby providing valuable insights into the molecular underpinnings of this process. Furthermore, we validated the presence of posttranslational modifications of KISS1 in breast cancer, adding to our understanding of its role in tumorigenesis. By shedding light on the tissue context‐dependent function of KISS1 and its implications for immunotherapy, our pancancer study offers novel perspectives on the oncogenic roles of KISS1 and provides potential avenues for the development of targeted therapies and diagnostic biomarkers.

Infectious wounds remain a formidable clinical challenge due to persistent bacterial colonization, uncontrolled inflammation, and impaired tissue regeneration. To address these issues, we developed a multifunctional immunoregulatory hydrogel by integrating curcumin (Cur) loaded polydopamine (PDA)-coated zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (Cur/ZIF/PDA) into a photo-cross-linkable hydrogel matrix derived from decellularized human amniotic membrane (dECMMA). This bioinspired hydrogel (dECMMA/ZIF/PDA) exhibited enhanced photothermal antibacterial activity, controlled drug release, and excellent biocompatibility. In vitro and in vivo studies demonstrated that the hydrogel not only efficiently eradicated bacteria but also promoted macrophage polarization toward an anti-inflammatory M2 phenotype, upregulated angiogenesis-related gene expression, and accelerated wound re-epithelialization and collagen remodeling. Notably, the synergistic action of photothermal therapy and immunomodulation significantly improved healing outcomes in a Staphylococcus aureus (S. aureus) infected wound model. This study presents a promising strategy for chronic wound management by leveraging naturally derived extracellular matrix components and multifunctional nanocarriers to orchestrate immune microenvironment remodeling and tissue regeneration.

A multifunctional hydrogel composed of PGDA and CMCS was developed via amide and hydrogen bonding. The hydrogel exhibits strong adhesion, antioxidant capacity, and rapid hemostasis, accelerating burn wound healing under NIR-enhanced conditions.