Helia Azimi
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Helia Azimi has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
- Abbas Aliaghaei
Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
1 shared publication - Mohammad-Amin Abdollahifar
Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
1 shared publication - Vajiheh Zarrinpour
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
1 shared publication
Latest Publications
- Open Access
- 1 March 2026
- Published by The Korean Society for Reproductive Medicine in Clinical and Experimental Reproductive Medicine
- Vol. 53 (1) , 38-46
Tramadol induces hormonal imbalance, histopathology, and altered ovarian gene expression in mice
Objective: Tramadol is a centrally acting analgesic with a modest opioid effect similar to morphine and codeine, but less potent; it is mainly prescribed for the treatment of mild to moderate pain. Tramadol exhibits both opioid and non-opioid properties, primarily affecting the central nervous system. Accordingly, the present study was designed to investigate the effects of tramadol on female reproductive function and ovarian toxicity, as well as to examine oocyte survival and follicular development in mice exposed to tramadol.Methods: Mice were treated with tramadol at 50 mg/kg daily for 3 weeks. Blood levels of the hormones estrogen and progesterone were measured. The ovaries of the mice were subjected to histological, immunohistochemical, and molecular studies.Results: Our results revealed that tramadol provoked ovarian atrophy by inducing oxidative stress, while also decreasing oocyte survival and impairing follicular development.Conclusion: Although further research is necessary, the findings indicate that tramadol could reduce fertility in female mice.
- 1 March 2026
- Published by The Korean Society for Reproductive Medicine in Clinical and Experimental Reproductive Medicine
- Vol. 53 (1) , 38-46
Open AccessTramadol induces hormonal imbalance, histopathology, and altered ovarian gene expression in mice
Objective: Tramadol is a centrally acting analgesic with a modest opioid effect similar to morphine and codeine, but less potent; it is mainly prescribed for the treatment of mild to moderate pain. Tramadol exhibits both opioid and non-opioid properties, primarily affecting the central nervous system. Accordingly, the present study was designed to investigate the effects of tramadol on female reproductive function and ovarian toxicity, as well as to examine oocyte survival and follicular development in mice exposed to tramadol.Methods: Mice were treated with tramadol at 50 mg/kg daily for 3 weeks. Blood levels of the hormones estrogen and progesterone were measured. The ovaries of the mice were subjected to histological, immunohistochemical, and molecular studies.Results: Our results revealed that tramadol provoked ovarian atrophy by inducing oxidative stress, while also decreasing oocyte survival and impairing follicular development.Conclusion: Although further research is necessary, the findings indicate that tramadol could reduce fertility in female mice.