Marta Pace
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Marta Pace has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Annamaria Cimini
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
1 shared publication - Chiara Giorgi
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
1 shared publication - Giorgia Lombardozzi
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
1 shared publication - Michele D’angelo
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
1 shared publication - Vanessa Castelli
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
1 shared publication
Latest Publications
- Open Access
- 3 August 2025
- Published by MDPI AG in Biomolecules
- Vol. 15 (8) , 1115
Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation
Aging is a complex, universal biological process characterized by the progressive and irreversible decline of physiological functions across multiple organ systems. This deterioration is primarily driven by cumulative cellular damage arising from both intrinsic and extrinsic stressors. The free radical theory of aging, first proposed by Denham Harman in 1956, highlights the role of reactive oxygen species (ROS), byproducts of normal metabolism, in driving oxidative stress and age-related degeneration. Emerging evidence emphasizes the importance of redox imbalance in the onset of neurodegenerative diseases and aging. Among the critical cellular defenses against oxidative stress are sulfur-containing amino acids, namely cysteine (Cys) and selenocysteine (Sec). Cysteine serves as a precursor for glutathione (GSH), a central intracellular antioxidant, while selenocysteine is incorporated into key antioxidant enzymes such as glutathione peroxidases (GPx) and thioredoxin reductases (TrxR). These molecules play pivotal roles in neutralizing ROS and maintaining redox homeostasis. This review aims to provide an updated and critical overview of the role of thiol-containing amino acids, specifically cysteine and selenocysteine, in the regulation of redox homeostasis during aging.
- 3 August 2025
- Published by MDPI AG in Biomolecules
- Vol. 15 (8) , 1115
Open AccessExploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation
Aging is a complex, universal biological process characterized by the progressive and irreversible decline of physiological functions across multiple organ systems. This deterioration is primarily driven by cumulative cellular damage arising from both intrinsic and extrinsic stressors. The free radical theory of aging, first proposed by Denham Harman in 1956, highlights the role of reactive oxygen species (ROS), byproducts of normal metabolism, in driving oxidative stress and age-related degeneration. Emerging evidence emphasizes the importance of redox imbalance in the onset of neurodegenerative diseases and aging. Among the critical cellular defenses against oxidative stress are sulfur-containing amino acids, namely cysteine (Cys) and selenocysteine (Sec). Cysteine serves as a precursor for glutathione (GSH), a central intracellular antioxidant, while selenocysteine is incorporated into key antioxidant enzymes such as glutathione peroxidases (GPx) and thioredoxin reductases (TrxR). These molecules play pivotal roles in neutralizing ROS and maintaining redox homeostasis. This review aims to provide an updated and critical overview of the role of thiol-containing amino acids, specifically cysteine and selenocysteine, in the regulation of redox homeostasis during aging.