Clara Plaza Alonso
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Clara Plaza Alonso has a total of 11 co-authors. Here are the top co-authors by number of shared publications:
- David Reigada
Molecular Neuroprotection Group, Instituto de Investigación Sanitaria de Castilla-La Mancha, National Hospital for Paraplegics (SESCAM), 45071 Toledo, Spain
2 shared publications - Eva Vargas
Systems Biology Unit, Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, 23071 Jaen, Spain
2 shared publications - Francisco José Esteban
Systems Biology Unit, Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, 23071 Jaen, Spain
2 shared publications - Javier García Flores
Molecular Neuroprotection Group, Instituto de Investigación Sanitaria de Castilla-La Mancha, National Hospital for Paraplegics (SESCAM), 45071 Toledo, Spain
2 shared publications - Manuel Nieto-Díaz
Hospital Nacional de Parapléjicos (SESCAM), Toledo, Spain.
2 shared publications - Miguel Nieto Hernández
Molecular Neuroprotection Group, Instituto de Investigación Sanitaria de Castilla-La Mancha, National Hospital for Paraplegics (SESCAM), 45071 Toledo, Spain
2 shared publications
Latest Publications
- Open Access
A Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs
The adult lumbar spinal cord plays a critical role in locomotor control and somatosensory integration, whose transcriptional architecture under physiological conditions has been characterized in various studies with restricted numbers of individuals (up to four). Here, we present an integrative single-nucleus RNA sequencing (snRNA-seq) atlas of the healthy adult mouse lumbar spinal cord, assembled from over 86,000 nuclei from 16 samples across five public datasets. Using a harmonized computational pipeline, we identify all major spinal cell lineages and resolve 17 transcriptionally distinct neuronal subtypes. A central novelty of our approach is the systematic inclusion of non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs) and pseudogenes. By comparing transcriptomic analyses based on coding-only, non-coding-only, and combined gene sets, we show that ncRNAs, despite accounting to a 10% of the recorded information of each cell, contribute to cell type-specific signatures. This resource offers a high-resolution, ncRNA-inclusive reference for the adult spinal cord and provides a foundation for future studies on spinal plasticity, injury, and regeneration.
Open AccessA Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs
The adult lumbar spinal cord plays a critical role in locomotor control and somatosensory integration, whose transcriptional architecture under physiological conditions has been characterized in various studies with restricted numbers of individuals (up to four). Here, we present an integrative single-nucleus RNA sequencing (snRNA-seq) atlas of the healthy adult mouse lumbar spinal cord, assembled from over 86,000 nuclei from 16 samples across five public datasets. Using a harmonized computational pipeline, we identify all major spinal cell lineages and resolve 17 transcriptionally distinct neuronal subtypes. A central novelty of our approach is the systematic inclusion of non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs) and pseudogenes. By comparing transcriptomic analyses based on coding-only, non-coding-only, and combined gene sets, we show that ncRNAs, despite accounting to a 10% of the recorded information of each cell, contribute to cell type-specific signatures. This resource offers a high-resolution, ncRNA-inclusive reference for the adult spinal cord and provides a foundation for future studies on spinal plasticity, injury, and regeneration.
- Open Access
- 4 August 2025
- Published by MDPI AG in Preprints.org
A Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs
The adult lumbar spinal cord plays a critical role in locomotor control and somatosensory integration, yet its transcriptional architecture remains incompletely characterized under physiological conditions. Here, we present an integrative single-nucleus RNA se-quencing (snRNA-seq) atlas of the healthy adult mouse lumbar spinal cord, assembled from over 86,000 nuclei across five public datasets. Using a harmonized computational pipeline, we identify all major spinal cell lineages and resolve 17 transcriptionally distinct neuronal subtypes. A central novelty of our approach is the systematic inclusion of non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs) and pseudogenes. By comparing transcriptomic analyses based on coding-only, non-coding-only, and combined gene sets, we demonstrate that ncRNAs contribute cell type-specific signatures that enhance neuronal subtype resolution. Differential expression analysis highlights lineage-associated ncRNAs enriched in sensory, inhibitory, and ependymal populations. This resource offers a high-resolution, ncRNA-inclusive refer-ence for the adult spinal cord and provides a foundation for future studies on spinal plasticity, injury, and regeneration.
- 4 August 2025
- Published by MDPI AG in Preprints.org
Open AccessA Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs
The adult lumbar spinal cord plays a critical role in locomotor control and somatosensory integration, yet its transcriptional architecture remains incompletely characterized under physiological conditions. Here, we present an integrative single-nucleus RNA se-quencing (snRNA-seq) atlas of the healthy adult mouse lumbar spinal cord, assembled from over 86,000 nuclei across five public datasets. Using a harmonized computational pipeline, we identify all major spinal cell lineages and resolve 17 transcriptionally distinct neuronal subtypes. A central novelty of our approach is the systematic inclusion of non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs) and pseudogenes. By comparing transcriptomic analyses based on coding-only, non-coding-only, and combined gene sets, we demonstrate that ncRNAs contribute cell type-specific signatures that enhance neuronal subtype resolution. Differential expression analysis highlights lineage-associated ncRNAs enriched in sensory, inhibitory, and ependymal populations. This resource offers a high-resolution, ncRNA-inclusive refer-ence for the adult spinal cord and provides a foundation for future studies on spinal plasticity, injury, and regeneration.