Sangkaran Pannerchelvan
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Sangkaran Pannerchelvan has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Chiu Peng Chan
Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia
1 shared publication - Huang Zhen Ni
Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia
1 shared publication - Joo Shun Tan
School of Industrial Technology, Universiti Sains Malaysia, Gelugor, Malaysia
1 shared publication - Mohd Shamzi Mohamed
Universiti Putra Malaysia
1 shared publication - Murni Halim
Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, Malaysia
1 shared publication - Nor Azman Kasan
Higher Institution Centre of Excellence (HICoE), Institute of Tropical Aquaculture and Fisheries, Universiti Malaysia Terengganu, Kuala Nerus, Malaysia
1 shared publication
Latest Publications
- 8 May 2025
- Published by Springer Nature in International Microbiology
- p. 1-13
Optimization of trace metal composition utilizing Taguchi orthogonal array enhances biomass and superoxide dismutase production in Tetraselmis chuii under mixotrophic condition: implications for antioxidant formulations
The natural ageing process in all organisms is majorly influenced by the production rate and dismutation of reactive oxygen species (ROS) within cells. Certain microalgae, such as Tetraselmis chuii, possess the ability to produce superoxide dismutase (SOD), a powerful antioxidant enzyme that mitigates oxidative damage caused by ROS during oxygen metabolism. This study investigated the impact of trace elements (nickel, manganese, copper, zinc, and iron) and nitrogen sources in the growth medium on both the biomass and SOD synthesis of T. chuii under mixotrophic conditions. Initially, the one-factor-at-a-time (OFAT) approach was employed to filter out the most significant factors in the production medium. Next, Taguchi orthogonal array method, known for its robustness in experimental design, was employed to analyse the effects of various media components on algal biomass and SOD production. Using only a few well-defined experimental sets, Taguchi’s L18 orthogonal array facilitated a 1.21-fold increase in biomass yield, reaching a maximum of 0.643 g/L. Furthermore, SOD activity was enhanced from 85.28 to 91.94% following optimization. Notably, nitrogen source, nitrogen concentration, and zinc concentration emerged as significant influencers of biomass and SOD production. The Taguchi optimization thereby improved SOD yield in a cost-effective manner. The heightened antioxidation activity of SOD holds promising applications in formulating antioxidants and topical ointments in pharmaceutical and cosmeceutical industries.
- 8 May 2025
- Published by Springer Nature in International Microbiology
- p. 1-13
Optimization of trace metal composition utilizing Taguchi orthogonal array enhances biomass and superoxide dismutase production in Tetraselmis chuii under mixotrophic condition: implications for antioxidant formulations
The natural ageing process in all organisms is majorly influenced by the production rate and dismutation of reactive oxygen species (ROS) within cells. Certain microalgae, such as Tetraselmis chuii, possess the ability to produce superoxide dismutase (SOD), a powerful antioxidant enzyme that mitigates oxidative damage caused by ROS during oxygen metabolism. This study investigated the impact of trace elements (nickel, manganese, copper, zinc, and iron) and nitrogen sources in the growth medium on both the biomass and SOD synthesis of T. chuii under mixotrophic conditions. Initially, the one-factor-at-a-time (OFAT) approach was employed to filter out the most significant factors in the production medium. Next, Taguchi orthogonal array method, known for its robustness in experimental design, was employed to analyse the effects of various media components on algal biomass and SOD production. Using only a few well-defined experimental sets, Taguchi’s L18 orthogonal array facilitated a 1.21-fold increase in biomass yield, reaching a maximum of 0.643 g/L. Furthermore, SOD activity was enhanced from 85.28 to 91.94% following optimization. Notably, nitrogen source, nitrogen concentration, and zinc concentration emerged as significant influencers of biomass and SOD production. The Taguchi optimization thereby improved SOD yield in a cost-effective manner. The heightened antioxidation activity of SOD holds promising applications in formulating antioxidants and topical ointments in pharmaceutical and cosmeceutical industries.