Morgan Belle
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Morgan Belle has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Alexis Berry
School of Medicine, Wayne State University, 540 E Canfield Street, Detroit, MI 48201, USA
1 shared publication - Austin Price
South Florida Multi-Specialty Medical Group, 8950 SW 74th Ct, Suite 1408, Miami, FL 33156, USA
1 shared publication - David Doyle
College of Medicine, Central Michigan University, Mount Pleasant, MI 48859, USA
1 shared publication - Margaret Ellen
Freeman NeuroSpine, 3401 McIntosh Circle, Suite 100, Joplin, MO 64804, USA
1 shared publication - Nicholas Panico
Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA
1 shared publication - Samuel Kim
School of Medicine, University of Missouri–Kansas City, Kansas City, MO 64108, USA
1 shared publication
Latest Publications
- Open Access
- 21 August 2025
- Published by MDPI AG in Journal of Vascular Diseases
- Vol. 4 (3) , 33
Cerebrovascular Disease as a Manifestation of Tick-Borne Infections: A Narrative Review
Background/Objectives: Tick-borne diseases (TBDs) are increasingly recognized as causes of both systemic and neurologic illness. While their impact on vascular health is established, their role in cerebrovascular disease remains underexplored. This review aims to synthesize clinical evidence linking TBDs with cerebrovascular events, focusing on mechanisms of injury, pathogen-specific associations, and treatment outcomes. Methods: A narrative review was conducted using Boolean keyword searches across PubMed, Scopus, EMBASE, and Web of Science. Relevant literature on ischemic and hemorrhagic stroke, cerebral vasculitis, and stroke mimics associated with TBDs was examined. The review included case reports, observational studies, and mechanistic research. Pathogen-specific data and disease characteristics were extracted and summarized. Results: Several tick-borne pathogens were associated with cerebrovascular complications. Borrelia burgdorferi was most commonly implicated and typically presented with large-vessel vasculitis. Rickettsia, Ehrlichia, and Anaplasma species caused endothelial injury through immune-mediated inflammation. Powassan virus and Crimean–Congo hemorrhagic fever virus exhibited central nervous system involvement and hemorrhagic potential. Babesia species contributed to vascular injury through thrombocytopenia and embolic complications. Neuroimaging frequently demonstrated multifocal stenoses and vessel wall inflammation. Antimicrobial treatment, particularly with doxycycline or ceftriaxone, was often effective, especially when administered early. Supportive care for stroke symptoms varied by presentation and underlying pathogen. Conclusions: Cerebrovascular disease caused by tick-borne pathogens is an underrecognized but potentially reversible condition. Despite diverse etiologies, most pathogens share a final common pathway of endothelial dysfunction. Early recognition and targeted antimicrobial therapy, combined with supportive stroke care, are essential to improving patient outcomes.
- 21 August 2025
- Published by MDPI AG in Journal of Vascular Diseases
- Vol. 4 (3) , 33
Open AccessCerebrovascular Disease as a Manifestation of Tick-Borne Infections: A Narrative Review
Background/Objectives: Tick-borne diseases (TBDs) are increasingly recognized as causes of both systemic and neurologic illness. While their impact on vascular health is established, their role in cerebrovascular disease remains underexplored. This review aims to synthesize clinical evidence linking TBDs with cerebrovascular events, focusing on mechanisms of injury, pathogen-specific associations, and treatment outcomes. Methods: A narrative review was conducted using Boolean keyword searches across PubMed, Scopus, EMBASE, and Web of Science. Relevant literature on ischemic and hemorrhagic stroke, cerebral vasculitis, and stroke mimics associated with TBDs was examined. The review included case reports, observational studies, and mechanistic research. Pathogen-specific data and disease characteristics were extracted and summarized. Results: Several tick-borne pathogens were associated with cerebrovascular complications. Borrelia burgdorferi was most commonly implicated and typically presented with large-vessel vasculitis. Rickettsia, Ehrlichia, and Anaplasma species caused endothelial injury through immune-mediated inflammation. Powassan virus and Crimean–Congo hemorrhagic fever virus exhibited central nervous system involvement and hemorrhagic potential. Babesia species contributed to vascular injury through thrombocytopenia and embolic complications. Neuroimaging frequently demonstrated multifocal stenoses and vessel wall inflammation. Antimicrobial treatment, particularly with doxycycline or ceftriaxone, was often effective, especially when administered early. Supportive care for stroke symptoms varied by presentation and underlying pathogen. Conclusions: Cerebrovascular disease caused by tick-borne pathogens is an underrecognized but potentially reversible condition. Despite diverse etiologies, most pathogens share a final common pathway of endothelial dysfunction. Early recognition and targeted antimicrobial therapy, combined with supportive stroke care, are essential to improving patient outcomes.