Mengdi Hu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Mengdi Hu has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
Pengjun Meng
Department of Physical Education, Xidian University, Xi’an, Shaanxi, China
1 shared publicationShen Jin
Office of Scientific Research, Ersha Sports Training Center of Guangdong Province, Guangzhou, Guangdong, China
1 shared publicationWei Liu
Department of Physical Education, Xidian University, Xi’an, Shaanxi, China
1 shared publicationXin Meng
Department of Physical Education, Xidian University, Xi’an, Shaanxi, China
1 shared publicationYifei Shen
Department of Physical Education, Xidian University, Xi’an, Shaanxi, China
1 shared publicationZhi Li
Department of Physical Education, Xidian University, Xi’an, Shaanxi, China
1 shared publication
Latest Publications
- Open Access
- 8 August 2025
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
- Vol. 13
The multifaceted impact of physical exercise on FoxO signaling pathways
This review explores the multifaceted impact of physical exercise on FoxO signaling pathways, which play a central role in cellular homeostasis, stress response, metabolism, and longevity. Exercise influences FoxO proteins—particularly FoxO1, FoxO3, FoxO4, and FoxO6—through diverse mechanisms, including phosphorylation, acetylation, and ubiquitination, determining their localization, transcriptional activity, and stability. Regular exercise modulates FoxO signaling by activating pathways like PI3K/AKT, AMPK, SIRT1, and IGF-1, promoting cellular resilience against oxidative stress, apoptosis, and metabolic dysfunction. The review highlights how exercise-induced modulation of FoxO pathways contributes to improved insulin sensitivity, muscle hypertrophy, cardiovascular health, neuroprotection, and reduced risks of chronic diseases, including metabolic syndrome, neurodegeneration, cardiovascular disease, and cancer. Additionally, it addresses the role of exercise in preventing muscle atrophy under various conditions, such as pharmacological interventions, aging, disease, and dietary factors. By enhancing FoxO signaling, exercise promotes anabolic processes, mitochondrial function, autophagy, and antioxidant defenses. Understanding the intricate relationship between exercise and FoxO pathways offers insights into developing therapeutic strategies to mitigate disease progression.
- 8 August 2025
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
- Vol. 13
Open AccessThe multifaceted impact of physical exercise on FoxO signaling pathways
This review explores the multifaceted impact of physical exercise on FoxO signaling pathways, which play a central role in cellular homeostasis, stress response, metabolism, and longevity. Exercise influences FoxO proteins—particularly FoxO1, FoxO3, FoxO4, and FoxO6—through diverse mechanisms, including phosphorylation, acetylation, and ubiquitination, determining their localization, transcriptional activity, and stability. Regular exercise modulates FoxO signaling by activating pathways like PI3K/AKT, AMPK, SIRT1, and IGF-1, promoting cellular resilience against oxidative stress, apoptosis, and metabolic dysfunction. The review highlights how exercise-induced modulation of FoxO pathways contributes to improved insulin sensitivity, muscle hypertrophy, cardiovascular health, neuroprotection, and reduced risks of chronic diseases, including metabolic syndrome, neurodegeneration, cardiovascular disease, and cancer. Additionally, it addresses the role of exercise in preventing muscle atrophy under various conditions, such as pharmacological interventions, aging, disease, and dietary factors. By enhancing FoxO signaling, exercise promotes anabolic processes, mitochondrial function, autophagy, and antioxidant defenses. Understanding the intricate relationship between exercise and FoxO pathways offers insights into developing therapeutic strategies to mitigate disease progression.