Shuai Zhang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Shuai Zhang has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Chen Bai
Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China
1 shared publication Mingcan Xu
Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China
1 shared publication- Xin Zhao
Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China
1 shared publication - Yanwu Jin
Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China
1 shared publication Ying Han
Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China
1 shared publicationYiqing Li
Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China
1 shared publication
Latest Publications
- Open Access
- 1 September 2025
- Published by Taylor & Francis in Drug Design, Development and Therapy
- Vol. ume 19, 8251-8263
Clinical Benefits and Challenges of Esketamine in Elderly Patients During the Perioperative Period
Ketamine is a classic intravenous anesthetic. Esketamine is a dextro-isomer of ketamine, with similar mechanism of action, mainly through non-competitive antagonism of N-methyl-D-aspartate receptors, higher potency and fewer adverse effects. The characteristics of esketamine include circulatory stimulation, bronchodilatation, inhibition of inflammation and dissociative anesthetic properties. Esketamine was approved for clinical practice in China in 2019, and has significant advantages for use in pediatric, maternal, elderly or shock patients. The clinical use of esketamine is currently receiving widespread attention. This article reviews the recent progress and limitations of clinical studies on the perioperative use of esketamine in elderly patients, covering its pharmacological properties, hemodynamic effects, analgesic benefits, and impacts on depression, sleep, and neurocognitive function, to provide theoretical reference for its application in anesthesia and offer dosage recommendations for elderly patients.
- 1 September 2025
- Published by Taylor & Francis in Drug Design, Development and Therapy
- Vol. ume 19, 8251-8263
Open AccessClinical Benefits and Challenges of Esketamine in Elderly Patients During the Perioperative Period
Ketamine is a classic intravenous anesthetic. Esketamine is a dextro-isomer of ketamine, with similar mechanism of action, mainly through non-competitive antagonism of N-methyl-D-aspartate receptors, higher potency and fewer adverse effects. The characteristics of esketamine include circulatory stimulation, bronchodilatation, inhibition of inflammation and dissociative anesthetic properties. Esketamine was approved for clinical practice in China in 2019, and has significant advantages for use in pediatric, maternal, elderly or shock patients. The clinical use of esketamine is currently receiving widespread attention. This article reviews the recent progress and limitations of clinical studies on the perioperative use of esketamine in elderly patients, covering its pharmacological properties, hemodynamic effects, analgesic benefits, and impacts on depression, sleep, and neurocognitive function, to provide theoretical reference for its application in anesthesia and offer dosage recommendations for elderly patients.