Caio Trevelin Sambo
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Caio Trevelin Sambo has a total of 14 co-authors. Here are the top co-authors by number of shared publications:
- Afonso Rafael da Silva Junior
Pathology Department, Laboratório de Microbiologia da Divisão de Laboratório Central, Hospital das Clínicas da Faculdade de Medicina USP (FMUSP), São Paulo 05403-010, Brazil
1 shared publication - Bianca Leal de Almeida
Hospital Infection Control and Infectious Diseases Service, Instituto do Cancer do Estado de Sao Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-000, Brazil
1 shared publication - Evangelina da Motta Pacheco Alves de Araujo
Pathology Department, Laboratório de Microbiologia da Divisão de Laboratório Central, Hospital das Clínicas da Faculdade de Medicina USP (FMUSP), São Paulo 05403-010, Brazil
1 shared publication - Flavia Rossi
Pathology Department, Laboratório de Microbiologia da Divisão de Laboratório Central, Hospital das Clínicas da Faculdade de Medicina USP (FMUSP), São Paulo 05403-010, Brazil
1 shared publication - Gabriel Fialkovitz
Unidade de Controle de Infecção Hospitalar do Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo , São Paulo, SP
1 shared publication - Gil Benard
Universidade de São Paulo, Brazil
1 shared publication
Latest Publications
- Open Access
- 23 September 2025
- Published by MDPI AG in Journal of Fungi
- Vol. 11 (10) , 692
Nine-Year Surveillance of Candida parapsilosis Candidemia in a Cardiothoracic ICU: Insights into Mortality and Resistance
Candida parapsilosis has emerged as a prominent cause of nosocomial candidemia, particularly among critically ill patients. The increasing prevalence of fluconazole-resistant C. parapsilosis (FR-Cp) poses major therapeutic challenges, especially in resource-limited settings. We conducted a retrospective study of 144 patients with C. parapsilosis candidemia admitted to two post-surgical ICUs at a Brazilian tertiary cardiothoracic hospital between 2016 and August 2024. Demographic, clinical, microbiological, and therapeutic data were analyzed. Predictors of 30-day mortality were identified through multivariate logistic regression. The incidence density of C. parapsilosis candidemia ranged from 2.93 to 8.31 per 1000 hospitalizations. Fluconazole resistance was identified in 81% of isolates. Overall 30-day mortality was 55%. Independent risk factors for mortality included cardiopathy (OR: 19.36, p = 0.006), higher SOFA scores (OR: 1.54, p = 0.003), parenteral nutrition (OR: 29.77, p = 0.013), and dialysis (OR: 6.59, p = 0.043), while longer treatment duration was protective (OR: 0.81, p < 0.001). Fluconazole resistance was not independently associated with increased mortality. In this cohort of critically ill patients, C. parapsilosis candidemia was associated with high mortality and a high prevalence of fluconazole resistance. Clinical outcomes were mainly driven by host-related and therapeutic factors rather than antifungal resistance alone.
- 23 September 2025
- Published by MDPI AG in Journal of Fungi
- Vol. 11 (10) , 692
Open AccessNine-Year Surveillance of Candida parapsilosis Candidemia in a Cardiothoracic ICU: Insights into Mortality and Resistance
Candida parapsilosis has emerged as a prominent cause of nosocomial candidemia, particularly among critically ill patients. The increasing prevalence of fluconazole-resistant C. parapsilosis (FR-Cp) poses major therapeutic challenges, especially in resource-limited settings. We conducted a retrospective study of 144 patients with C. parapsilosis candidemia admitted to two post-surgical ICUs at a Brazilian tertiary cardiothoracic hospital between 2016 and August 2024. Demographic, clinical, microbiological, and therapeutic data were analyzed. Predictors of 30-day mortality were identified through multivariate logistic regression. The incidence density of C. parapsilosis candidemia ranged from 2.93 to 8.31 per 1000 hospitalizations. Fluconazole resistance was identified in 81% of isolates. Overall 30-day mortality was 55%. Independent risk factors for mortality included cardiopathy (OR: 19.36, p = 0.006), higher SOFA scores (OR: 1.54, p = 0.003), parenteral nutrition (OR: 29.77, p = 0.013), and dialysis (OR: 6.59, p = 0.043), while longer treatment duration was protective (OR: 0.81, p < 0.001). Fluconazole resistance was not independently associated with increased mortality. In this cohort of critically ill patients, C. parapsilosis candidemia was associated with high mortality and a high prevalence of fluconazole resistance. Clinical outcomes were mainly driven by host-related and therapeutic factors rather than antifungal resistance alone.