Emma Birkeskov
Research Subjects
Emma Birkeskov has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- David Landry
Univ. Toulouse, CNRS, INRAE, LIPME , Castanet-Tolosan
1 shared publication - Jens Stougaard
Department of Molecular Biology and Genetics, Aarhus University
1 shared publication - Kasper Røjkjær Andersen
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
1 shared publication - Malita M. M. Nørgaard
Department of Molecular Biology and Genetics, Aarhus University, Aarhus C 8000, Denmark
1 shared publication - Nikolaj B. Abel
Department of Molecular Biology and Genetics, Aarhus University, Aarhus C 8000, Denmark
1 shared publication
Latest Publications
- Open Access
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis
Legume symbiosis with nitrogen-fixing bacteria is controlled by a cascade of signaling events leading to root nodule development. While plant cell-surface receptors initiate this process, the link between receptors and cytoplasmic signaling components remains unclear. Here we identify Early Phosphorylated Protein 1 (EPP1) as a central mediator of this pathway. EPP1 is recruited to the activated SYMRK receptor, where it is phosphorylated on a key serine residue, an event essential and sufficient to propagate symbiotic signaling. We provide structural and functional validation of the SYMRK-EPP1 signaling complex and demonstrate that EPP1 is required for root nodule formation. Synthetic engineering of the SYMRK-EPP1 interaction bypasses the need for symbiotic bacteria to initiate the pathway and triggers nodule organogenesis. These findings establish EPP1 as a crucial cytoplasmic component between receptor activation and intracellular signaling, advancing our understanding of nitrogen-fixing symbiosis.
Open AccessEPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis
Legume symbiosis with nitrogen-fixing bacteria is controlled by a cascade of signaling events leading to root nodule development. While plant cell-surface receptors initiate this process, the link between receptors and cytoplasmic signaling components remains unclear. Here we identify Early Phosphorylated Protein 1 (EPP1) as a central mediator of this pathway. EPP1 is recruited to the activated SYMRK receptor, where it is phosphorylated on a key serine residue, an event essential and sufficient to propagate symbiotic signaling. We provide structural and functional validation of the SYMRK-EPP1 signaling complex and demonstrate that EPP1 is required for root nodule formation. Synthetic engineering of the SYMRK-EPP1 interaction bypasses the need for symbiotic bacteria to initiate the pathway and triggers nodule organogenesis. These findings establish EPP1 as a crucial cytoplasmic component between receptor activation and intracellular signaling, advancing our understanding of nitrogen-fixing symbiosis.