Suwipa Intakhiao

This study characterized the in vitro properties of a Hom pathum rice extract and explored the clinical performance of a facial mask containing the extract. In this single-center, assessor-blinded, two-arm randomized controlled trial, 60 patch-test-negative healthy adults aged 30–50 years were allocated 1:1 to a no-treatment control group or to a treatment group that applied a multi-ingredient facial mask containing 0.27% (w/w) Hom pathum rice extract for 30 min twice weekly for 12 weeks. Hydration, elasticity, oiliness, melanin, and erythema were assessed at the forehead, cheek, and chin. Complete-case week-12 comparisons used ANCOVA adjusted for the corresponding baseline value, age, and sex, followed by Benjamini–Hochberg correction across the 15 between-group comparisons. Forty-nine participants completed follow-up (control, 24; treatment, 25). The ethanolic extract showed 55% DPPH radical-scavenging activity, an IC₅₀ of 2.29 ± 0.02 mg/mL, and a total phenolic content of 0.01 ± 0.00 mg GAE/mg extract; total flavonoids were below the assay detection limit at 5 mg/mL. Six comparisons were nominally significant, of which three remained significant after false-discovery-rate correction: higher forehead hydration (adjusted mean difference, 9.42 AU; 95% CI, 2.79 to 16.06; p = 0.007; q = 0.033), lower chin oiliness (−33.15 μg/cm²; 95% CI, −52.40 to −13.89; p = 0.001; q = 0.022), and lower cheek melanin (−68.65 AU; 95% CI, −112.89 to −24.41; p = 0.003; q = 0.026). However, none of the 15 comparisons reached nominal or FDR-adjusted significance in the intention-to-treat multiple-imputation sensitivity analysis (all p ≥ 0.092). No intervention-related adverse effects were recorded among the enrolled patch-test-negative participants. These findings apply to the formulation and application procedure as a whole and were not statistically confirmed in the intention-to-treat sensitivity analysis; they therefore warrant confirmation in an adequately powered, double-blind, vehicle-controlled trial with a prespecified primary outcome. ClinicalTrials.gov: NCT06475222. Funding: Burapha University, Thailand Science Research and Innovation, and the National Science Research and Innovation Fund.

This study aimed to investigate the effects of a facial serum containing Tubtim Chumphae rice extract on skin hydration, elasticity, oiliness, pigmentation, and erythema in healthy adults aged 30–50 years. Thirty participants applied two facial serums daily to opposite sides of the face for 12 weeks: (1) a serum containing Tubtim Chumphae rice extract (treatment intervention) and (2) a standard serum formulation containing 2% α-arbutin (control intervention). Skin hydration, elasticity, oiliness, melanin, and erythema were assessed at baseline and after the intervention using non-invasive skin measurement techniques. At baseline, no significant differences were observed between facial sides for any outcome. After 12 weeks, the side treated with the treatment intervention demonstrated significant within-side improvements in skin hydration at the forehead, skin elasticity at the cheeks and chin, and reductions in melanin and erythema in selected facial regions (all p < 0.05). However, paired split-face comparisons revealed that the treatment intervention produced significantly greater skin hydration at the cheek (mean difference = 3.88 AU, 95% CI: 0.23–7.53 AU, p = 0.039) and significantly greater skin elasticity at the forehead (mean difference = 0.090, 95% CI: 0.011–0.169, p = 0.028) compared with the control intervention. In addition, skin oiliness at the cheek was significantly lower on the side treated with the treatment intervention (mean difference = −6.62 µg/cm², 95% CI: −12.62 to −0.62 µg/cm², p = 0.032). No significant between-intervention differences were observed for melanin or erythema at any facial region. These findings suggest that topical application of a facial serum containing Tubtim Chumphae rice extract may improve skin hydration and elasticity while reducing skin oiliness in healthy middle-aged adults. However, no significant advantages over a standard 2% α-arbutin serum were observed for skin pigmentation or erythema after 12 weeks of treatment. Clinical Trial Registration: ClinicalTrials.gov, NCT06475222.

Background: Salacca zalacca (snake fruit) is rich in antioxidants, polyphenols, organic acids, and vitamin C. This study aimed to evaluate the effectiveness of body massage oil containing snake fruit extract, in conjunction with traditional Thai massage (TTM), on skin quality in healthy individuals. Methods: Seventy‐one participants aged 18–35 years were randomly assigned to one of three groups: (1) control group ( n = 23) receiving TTM without oil; (2) Treatment‐1 group ( n = 23) receiving TTM with pure coconut oil; and (3) Treatment‐2 group ( n = 25) receiving TTM with snake fruit extract–infused oil. All participants received 60‐min massages once weekly for 12 weeks. Skin parameters including elasticity, moisture, melanin, and oiliness were assessed at the neck, back, arm, and leg regions. Results: After 12 weeks, skin elasticity significantly improved at all assessed regions in all groups ( p < 0.001), with no significant between‐group differences. Skin melanin levels significantly decreased at the back and leg regions across all groups ( p < 0.05), with no between‐group differences observed. Skin moisture significantly increased at the leg region only in the Treatment‐2 group ( p = 0.003). Skin oiliness significantly increased at all measured regions in both oil‐based groups (Treatment‐1 and Treatment‐2) ( p < 0.05) and was significantly higher than in the control group ( p < 0.05), except at the back region in the Treatment‐2 group. Conclusion: Massage oil containing snake fruit extract demonstrated specific benefits in enhancing skin oiliness and localized moisture. However, it did not confer overall superiority over conventional coconut oil, while improvements in elasticity and melanin appeared to be primarily attributable to the massage technique itself. Trial Registration: ClinicalTrials.gov Identifier: NCT06227260

Long COVID is characterized by persistent symptoms associated with chronic inflammation and oxidative stress. While high-intensity interval training (HIIT) and supplementation with antioxidants such as Triphala have demonstrated individual therapeutic benefits, their combined effects remain unclear. This study aimed primarily to evaluate the effects of an 8-week HIIT program on markers of inflammation, oxidative stress, and exercise-related symptoms in individuals with long COVID, and secondarily to explore whether Triphala supplementation provided additional benefits. A total of 104 participants (aged 18–59 years) were randomized into three groups—control (placebo), HIIT (cycling for 28 min/day, 3 days/week), and combined (HIIT + Triphala, 1000 mg/day)—for 8 weeks. The biomarkers assessed included interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), protein carbonyls, and superoxide dismutase (SOD) activity. Following the intervention, significant reductions in IFN-γ, TNF-α, MDA, protein carbonyls, and rating of perceived exertion were observed in both the HIIT and combined groups (p < 0.05), with no significant differences between the two. SOD activity significantly increased in all groups, including the control group (p < 0.05), with no between-group differences. An 8-week HIIT program appears to be effective in reducing inflammation, oxidative stress, and dyspnea in individuals with long COVID. Triphala supplementation did not provide any additional statistically significant benefit but was safe and well tolerated.