Julian Gendreau
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Julian Gendreau has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
- Bibhas Amatya
University of Maryland School of Medicine Baltimore Maryland USA
1 shared publication - Mickey E. Abraham
Department of Neurosurgery, University of California San Diego, La Jolla, CA 92093, USA
1 shared publication - Ritvik Pulya
Department of Biomedical Engineering, Johns Hopkins Whiting School of Engineering, Baltimore, USA
1 shared publication
Latest Publications
- 21 October 2025
- Published by Springer Nature in Child's Nervous System
- Vol. 41 (1) , 1-11
Stereotactic radiosurgery in the treatment of pediatric cerebral cavernous malformations: a systematic review and meta-analysis of outcomes and safety
Cerebral cavernous malformations (CCMs) are clusters of dilated, thin-walled vascular channels that pose significant neurological risks, particularly in pediatric patients. While stereotactic radiosurgery (SRS) has been explored as a non-invasive treatment modality, its safety and efficacy in children remain incompletely defined. We conducted a systematic review and meta-analysis of single-arm proportions after SRS for pediatric CCMs. PubMed and the Cochrane Library were searched; four retrospective cohort studies met inclusion criteria. Random-effects pooled proportions were calculated for key outcomes. Post-SRS seizure proportion (three studies; n = 73) was 0.23 (95% CI, 0.11–0.37; I2 = 23.7%; p = 0.27). A lesion-volume decrease was observed in 0.34 (0.18–0.67; I2 = 82.1%; p = 0.0037). Post-SRS hemorrhage proportion (four studies) was 0.22 (0.09–0.52; I2 = 76.1%; p = 0.0058). Adverse radiation effects (AREs) were uncommon but variably reported. Findings suggest that radiosurgery may provide benefit in selected pediatric CCMs, though small sample sizes and study heterogeneity warrant cautious interpretation.
- 21 October 2025
- Published by Springer Nature in Child's Nervous System
- Vol. 41 (1) , 1-11
Stereotactic radiosurgery in the treatment of pediatric cerebral cavernous malformations: a systematic review and meta-analysis of outcomes and safety
Cerebral cavernous malformations (CCMs) are clusters of dilated, thin-walled vascular channels that pose significant neurological risks, particularly in pediatric patients. While stereotactic radiosurgery (SRS) has been explored as a non-invasive treatment modality, its safety and efficacy in children remain incompletely defined. We conducted a systematic review and meta-analysis of single-arm proportions after SRS for pediatric CCMs. PubMed and the Cochrane Library were searched; four retrospective cohort studies met inclusion criteria. Random-effects pooled proportions were calculated for key outcomes. Post-SRS seizure proportion (three studies; n = 73) was 0.23 (95% CI, 0.11–0.37; I2 = 23.7%; p = 0.27). A lesion-volume decrease was observed in 0.34 (0.18–0.67; I2 = 82.1%; p = 0.0037). Post-SRS hemorrhage proportion (four studies) was 0.22 (0.09–0.52; I2 = 76.1%; p = 0.0058). Adverse radiation effects (AREs) were uncommon but variably reported. Findings suggest that radiosurgery may provide benefit in selected pediatric CCMs, though small sample sizes and study heterogeneity warrant cautious interpretation.