Jonathan Ruiz-Triviño
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Jonathan Ruiz-Triviño has a total of 34 co-authors. Here are the top co-authors by number of shared publications:
- David Aguillon
Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
3 shared publications A. Claudio Cuello
Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada; Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Department of Neurology & Neurosurgery, McGill University, Montreal, Quebec, Canada; Department of Anatomy & Cell Biology, McGill University, Montreal, Quebec, Canada; Department of Pharmacology, Oxford University, Oxford, United Kingdom; Affiliated member, Karolinska Institutet, Stockholm, Sweden
1 shared publication- Alpana Singh
Center for Neurogastroenterology, Department of Medicine, Johns Hopkins University – School of Medicine
1 shared publication Bing He
Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA
1 shared publication- Catarina Tristão-Pereira
Boston University
1 shared publication Daniela Giraldo
Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia
1 shared publication
Latest Publications
- Open Access
Electrodermal Activity as a Potential Diagnostic Biomarker for Alzheimer’s Disease: A Pilot Study
Alzheimer’s disease (AD), the leading cause of dementia, lacks an inexpensive and non-invasive method for early detection. Here, we investigate whether electrodermal activity (EDA), a measure of changes in electrical conductance at the skin’s surface, can offer a convenient avenue for AD screening by capturing the autonomic dysfunction associated with the disease’s pathology. As few studies have comprehensively examined EDA’s utility as a standalone biomarker for AD, we conducted a pilot study with 10 cognitively healthy controls and 20 patients with AD, evaluating EDA recordings collected during an orthostatic test and a Montreal Cognitive Assessment (MoCA). The AD group included both carriers from Colombian kindreds affected by autosomal-dominant AD and patients with sporadic late-onset AD. We compared EDA features between groups using statistical analysis and tested whether machine learning models could separate the two groups using these features. During the MoCA, phasic EDA measures, specifically the number of skin conductance responses (NSSCR) and mean time-variant sympathetic tone (TVSymp), were significantly lower in the AD group than in controls (NSSCR: , Cohen’s ; mean TVSymp: , ), suggesting a blunted sympathetic response to cognitive stress in AD. No significant between-group differences were observed during the orthostatic test (all ). A random forest classifier trained on MoCA-derived EDA features achieved a balanced accuracy of 78% (95% CI 60 to 93%; 75% sensitivity, 80% specificity, AUROC 0.75), with phasic features contributing most to performance. Performance did not differ significantly from that of the support vector machine or logistic regression models. These results provide preliminary, hypothesis-generating evidence for the utility of EDA in screening for AD. The small sample size, unequal group allocation, sex imbalance, and substantial mean age disparity between groups (≈23.5 years) limit the strength of these conclusions and necessitate replication in larger, age- and sex-matched cohorts that include prodromal stages.Open AccessElectrodermal Activity as a Potential Diagnostic Biomarker for Alzheimer’s Disease: A Pilot Study
Alzheimer’s disease (AD), the leading cause of dementia, lacks an inexpensive and non-invasive method for early detection. Here, we investigate whether electrodermal activity (EDA), a measure of changes in electrical conductance at the skin’s surface, can offer a convenient avenue for AD screening by capturing the autonomic dysfunction associated with the disease’s pathology. As few studies have comprehensively examined EDA’s utility as a standalone biomarker for AD, we conducted a pilot study with 10 cognitively healthy controls and 20 patients with AD, evaluating EDA recordings collected during an orthostatic test and a Montreal Cognitive Assessment (MoCA). The AD group included both carriers from Colombian kindreds affected by autosomal-dominant AD and patients with sporadic late-onset AD. We compared EDA features between groups using statistical analysis and tested whether machine learning models could separate the two groups using these features. During the MoCA, phasic EDA measures, specifically the number of skin conductance responses (NSSCR) and mean time-variant sympathetic tone (TVSymp), were significantly lower in the AD group than in controls (NSSCR: , Cohen’s ; mean TVSymp: , ), suggesting a blunted sympathetic response to cognitive stress in AD. No significant between-group differences were observed during the orthostatic test (all ). A random forest classifier trained on MoCA-derived EDA features achieved a balanced accuracy of 78% (95% CI 60 to 93%; 75% sensitivity, 80% specificity, AUROC 0.75), with phasic features contributing most to performance. Performance did not differ significantly from that of the support vector machine or logistic regression models. These results provide preliminary, hypothesis-generating evidence for the utility of EDA in screening for AD. The small sample size, unequal group allocation, sex imbalance, and substantial mean age disparity between groups (≈23.5 years) limit the strength of these conclusions and necessitate replication in larger, age- and sex-matched cohorts that include prodromal stages. - Open Access
- 5 May 2026
- Published by Elsevier in The Journal Of Prevention of Alzheimer's Disease
- Vol. 13 (6) , 100578
Associations of plasma biomarkers with age in the presenilin-1 E280A autosomal dominant Alzheimer's disease kindred
- 5 May 2026
- Published by Elsevier in The Journal Of Prevention of Alzheimer's Disease
- Vol. 13 (6) , 100578
Open AccessAssociations of plasma biomarkers with age in the presenilin-1 E280A autosomal dominant Alzheimer's disease kindred
- Open Access
- 13 April 2026
- Published by Elsevier in SSRN Electronic Journal
4R Tauopathies and Phenotypic Overlap: A Case Report
Four-repeat (4R) tauopathies, such as Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD), often exhibit considerable phenotypic overlap, which complicates invivo diagnosis. This report presents a 62-year-old woman who initially presented clinical features of corticobasal syndrome, such as asymmetric parkinsonism, fixed right limb dystonia, and orobuccal apraxia. The later development of supranuclear vertical gaze palsy and recurrent falls led to a revised diagnosis of probable PSP. Neuropsychological evaluation identified a non-amnestic major neurocognitive disorder with severe executive dysfunction, attentional deficits, and apraxia. Neuroimaging contributed critical diagnostic information: FDG-PET revealed severe asymmetric cortical hypometabolism in the left frontoparietal regions, and MRI demonstrated marked midbrain atrophy with the hummingbird sign. Volumetric analysis further confirmed asymmetric cortical atrophy, predominantly in the left frontoparietal areas, as well as reduced brainstem volume. Negative genetic testing supported a sporadic etiology. This case underscores the complex clinical overlap within the 4R tauopathy spectrum, illustrating that PSP may present with a CBS phenotype. The findings support the clinical value of categorizing these disorders as probable 4R-tauopathies to facilitate early recognition. Integration of clinical, radiological, and volumetric data is crucial for diagnostic precision.
- 13 April 2026
- Published by Elsevier in SSRN Electronic Journal
Open Access4R Tauopathies and Phenotypic Overlap: A Case Report
Four-repeat (4R) tauopathies, such as Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD), often exhibit considerable phenotypic overlap, which complicates invivo diagnosis. This report presents a 62-year-old woman who initially presented clinical features of corticobasal syndrome, such as asymmetric parkinsonism, fixed right limb dystonia, and orobuccal apraxia. The later development of supranuclear vertical gaze palsy and recurrent falls led to a revised diagnosis of probable PSP. Neuropsychological evaluation identified a non-amnestic major neurocognitive disorder with severe executive dysfunction, attentional deficits, and apraxia. Neuroimaging contributed critical diagnostic information: FDG-PET revealed severe asymmetric cortical hypometabolism in the left frontoparietal regions, and MRI demonstrated marked midbrain atrophy with the hummingbird sign. Volumetric analysis further confirmed asymmetric cortical atrophy, predominantly in the left frontoparietal areas, as well as reduced brainstem volume. Negative genetic testing supported a sporadic etiology. This case underscores the complex clinical overlap within the 4R tauopathy spectrum, illustrating that PSP may present with a CBS phenotype. The findings support the clinical value of categorizing these disorders as probable 4R-tauopathies to facilitate early recognition. Integration of clinical, radiological, and volumetric data is crucial for diagnostic precision.
- Open Access
- 2 October 2025
- Published by Asociacion Colombiana de Neurologia in Acta Neurológica Colombiana
- Vol. 41 (4)
Familial aggregation of restless legs syndrome: A case report of four affected relatives in a Colombian family, with a narrative review
Introduction: Restless legs syndrome (RLS) is a neurological sensorimotor disorder with both sporadic and familial forms, the latter frequently associated with a genetic basis. Materials and methods: Four members of a family from Yarumal, Antioquia, with symptoms suggestive of restless legs syndrome, underwent a neurological evaluation, including a workup for secondary causes. The diagnosis was established by applying the clinical criteria proposed by the International Classification of Sleep Disorders, Third Edition, Text Revision (ICSD-3-TR), thereby ensuring greater diagnostic certainty. Additionally, a narrative review was conducted using Medline to explore the genetic component of restless legs syndrome. Results: Genetic studies, including genome-wide association studies (GWAS) and whole-exome sequencing (WES), have identified several risk variants associated with restless legs syndrome. In vivo mouse and zebrafish models have elucidated the role of some variants in the neurobiology of this syndrome. Conclusion: This is the first case report of a Colombian family with four documented members and two deceased members affected by restless legs syndrome across three generations. The family exhibits an autosomal dominant inheritance pattern, although with significant clinical variability. Despite its complexity, restless legs syndrome demonstrates a significant genetic component contributing to its familial aggregation.
- 2 October 2025
- Published by Asociacion Colombiana de Neurologia in Acta Neurológica Colombiana
- Vol. 41 (4)
Open AccessFamilial aggregation of restless legs syndrome: A case report of four affected relatives in a Colombian family, with a narrative review
Introduction: Restless legs syndrome (RLS) is a neurological sensorimotor disorder with both sporadic and familial forms, the latter frequently associated with a genetic basis. Materials and methods: Four members of a family from Yarumal, Antioquia, with symptoms suggestive of restless legs syndrome, underwent a neurological evaluation, including a workup for secondary causes. The diagnosis was established by applying the clinical criteria proposed by the International Classification of Sleep Disorders, Third Edition, Text Revision (ICSD-3-TR), thereby ensuring greater diagnostic certainty. Additionally, a narrative review was conducted using Medline to explore the genetic component of restless legs syndrome. Results: Genetic studies, including genome-wide association studies (GWAS) and whole-exome sequencing (WES), have identified several risk variants associated with restless legs syndrome. In vivo mouse and zebrafish models have elucidated the role of some variants in the neurobiology of this syndrome. Conclusion: This is the first case report of a Colombian family with four documented members and two deceased members affected by restless legs syndrome across three generations. The family exhibits an autosomal dominant inheritance pattern, although with significant clinical variability. Despite its complexity, restless legs syndrome demonstrates a significant genetic component contributing to its familial aggregation.