Liqiang Xie
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Liqiang Xie has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Ce Zhang
State Key Laboratory of Photon-Technology in Western China Energy, Institute of Photonics and Photon-Technology, Northwest University, No. 1, Xuefu Avenue, Xi’an 710127, China
1 shared publication - Dan Sun
State Key Laboratory of Photon-Technology in Western China Energy, Institute of Photonics and Photon-Technology, Northwest University, No. 1, Xuefu Avenue, Xi’an 710127, China
1 shared publication - Jiangcun Yang
Department of Transfusion Medicine, Shaanxi Provincial People’s Hospital, Xi’an, China
1 shared publication - Wenyan Liu
State Key Laboratory of Photon-Technology in Western China Energy, Shaanxi Provincial Key Laboratory of Optoelectronic Technology, Institute of Photonics and Photon-Technology, Northwest University, No. 1, Xuefu Avenue, Xi’an 710127, China
1 shared publication - Xiaobo Gong
Key Laboratory of Hydrodynamics (Ministry of Education), Department of Engineering Mechanics, School of Ocean and Civil Engineering, Shanghai Jiao Tong University 1 , Shanghai 200240
1 shared publication
Latest Publications
- Open Access
- 14 November 2025
- Published by MDPI AG in Biosensors
- Vol. 15 (11) , 758
A Microfluidic Device for Detecting the Deformability of Red Blood Cells
Red blood cell (RBC) deformability is a critical biophysical property that enables effective passage of RBCs through microvasculature and ensures proper oxygen delivery. Impairment of this property is associated with various pathological conditions, including type 2 diabetes mellitus (T2DM). In this study, we developed an automated microfluidic platform for high-throughput and real-time assessment of RBC deformability under controlled flow conditions. The device features a structured microchannel design and integrated imaging to quantify individual cell deformation responses. Comparative analyses of RBCs from healthy individuals and T2DM patients revealed significant reductions in deformability in the diabetic group. In vivo validation using a diabetic mouse model further confirmed the progressive decline in RBC deformability under chronic hyperglycemia. This microfluidic approach provides a robust and efficient tool for characterizing RBC mechanical properties, offering potential for disease monitoring and clinical diagnostic applications.
- 14 November 2025
- Published by MDPI AG in Biosensors
- Vol. 15 (11) , 758
Open AccessA Microfluidic Device for Detecting the Deformability of Red Blood Cells
Red blood cell (RBC) deformability is a critical biophysical property that enables effective passage of RBCs through microvasculature and ensures proper oxygen delivery. Impairment of this property is associated with various pathological conditions, including type 2 diabetes mellitus (T2DM). In this study, we developed an automated microfluidic platform for high-throughput and real-time assessment of RBC deformability under controlled flow conditions. The device features a structured microchannel design and integrated imaging to quantify individual cell deformation responses. Comparative analyses of RBCs from healthy individuals and T2DM patients revealed significant reductions in deformability in the diabetic group. In vivo validation using a diabetic mouse model further confirmed the progressive decline in RBC deformability under chronic hyperglycemia. This microfluidic approach provides a robust and efficient tool for characterizing RBC mechanical properties, offering potential for disease monitoring and clinical diagnostic applications.