Zijiao Zhang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Zijiao Zhang has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Chenghua Tian
School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China
1 shared publication - Chi Zhang
Rehabilitation Medicine Department, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China
1 shared publication - Jianbo Lei
Center for Medical Informatics, Advanced Institute of Clinical Medicine, Peking University, Beijing, China
1 shared publication - Jun Liang
School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China
1 shared publication Tongyu Ma
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China
1 shared publication- Weihong Huang
Xiangya Hospital of Central South University (National Clinical Research Center for Geriatric Disorders (Xiangya Hospital)), Changsha, China
1 shared publication
Latest Publications
- 11 November 2025
- Published by SAGE Publications in International Journal of Stroke
- Vol. 21 (4) , 447-456
Association of total and moderate-to-vigorous physical activity with stroke risk: A dose–response meta-analysis of 2,639,086 participants from 14 international prospective cohort studies
Background: Stroke is the second leading cause of death and third leading cause of disability globally. The dose–response relationship between physical activity (PA), particularly moderate-to-vigorous physical activity (MVPA), and stroke risk remains unclear, with limited sex-specific evidence. Aims: To examine the dose–response associations of total PA and MVPA with stroke risk, considering sex and subtype differences. Methods: A systematic review and dose–response meta-analysis of prospective cohort studies published between 2013 and 2024, with follow-up durations ranging from 4.9 to 17.9 years, were conducted. PA exposures were standardized to MET-hours per week (MET-h/wk), and incident stroke was the primary outcome. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled using random-effects models. Dose–response associations were assessed using restricted cubic spline models. Analyses stratified by sex and subtype were performed when available. Results: Fourteen cohorts (n = 2,639,086) were included. Total PA showed a nonlinear inverse association with stroke risk: each 10 MET-h/wk increment reduced risk by 1% up to 130 MET-h/wk, corresponding to a 13% maximum reduction, after which benefits plateaued. MVPA exhibited an L-shaped association (P < 0.001), with the greatest benefit (19% reduction) at 19 MET-h/wk, followed by a gradual increase in risk. Sex-stratified analysis revealed a J-shaped pattern in females (optimal 10–15 MET-h/wk; 18% reduction). For males, the HR was 0.89 (95% CI: 0.70–1.13), and a nonlinear model could not be established due to limited data. In ischemic stroke, dose–response patterns paralleled those for total stroke. Conclusions: The study found a significant dose–response relationship between total PA and MVPA with stroke risk. Optimal prevention was observed at 130 MET-h/wk for total PA and 19 MET-h/wk for MVPA. Evidence in males and for hemorrhagic stroke remains limited and warrants further study.
- 11 November 2025
- Published by SAGE Publications in International Journal of Stroke
- Vol. 21 (4) , 447-456
Association of total and moderate-to-vigorous physical activity with stroke risk: A dose–response meta-analysis of 2,639,086 participants from 14 international prospective cohort studies
Background: Stroke is the second leading cause of death and third leading cause of disability globally. The dose–response relationship between physical activity (PA), particularly moderate-to-vigorous physical activity (MVPA), and stroke risk remains unclear, with limited sex-specific evidence. Aims: To examine the dose–response associations of total PA and MVPA with stroke risk, considering sex and subtype differences. Methods: A systematic review and dose–response meta-analysis of prospective cohort studies published between 2013 and 2024, with follow-up durations ranging from 4.9 to 17.9 years, were conducted. PA exposures were standardized to MET-hours per week (MET-h/wk), and incident stroke was the primary outcome. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled using random-effects models. Dose–response associations were assessed using restricted cubic spline models. Analyses stratified by sex and subtype were performed when available. Results: Fourteen cohorts (n = 2,639,086) were included. Total PA showed a nonlinear inverse association with stroke risk: each 10 MET-h/wk increment reduced risk by 1% up to 130 MET-h/wk, corresponding to a 13% maximum reduction, after which benefits plateaued. MVPA exhibited an L-shaped association (P < 0.001), with the greatest benefit (19% reduction) at 19 MET-h/wk, followed by a gradual increase in risk. Sex-stratified analysis revealed a J-shaped pattern in females (optimal 10–15 MET-h/wk; 18% reduction). For males, the HR was 0.89 (95% CI: 0.70–1.13), and a nonlinear model could not be established due to limited data. In ischemic stroke, dose–response patterns paralleled those for total stroke. Conclusions: The study found a significant dose–response relationship between total PA and MVPA with stroke risk. Optimal prevention was observed at 130 MET-h/wk for total PA and 19 MET-h/wk for MVPA. Evidence in males and for hemorrhagic stroke remains limited and warrants further study.