Irene Orozco Cifuentes
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Irene Orozco Cifuentes has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
Adrián Domínguez García
Servicio de Farmacia, Hospital Universitario Severo Ochoa, Leganés, Spain
1 shared publicationBenito García Díaz
Servicio de Farmacia, Hospital Universitario Severo Ochoa, Leganés, Spain
1 shared publication- Carmen de Cáceres Velasco
Pharmacy Service, Hospital Universitario Infanta Cristina, 9 de Junio, Av. 2, 28981 Parla, Spain
1 shared publication Elena García Benayas
Servicio de Farmacia, Hospital Universitario Severo Ochoa, Leganés, Spain
1 shared publication- José Antonio Martínez Consuegra
Internal Medicine Service, Hospital Universitario Infanta Cristina, 9 de Junio, Av. 2, 28981 Parla, Spain
1 shared publication María Jiménez Meseguer
Servicio de Farmacia, Hospital Universitario Severo Ochoa, Leganés, Spain
1 shared publication
Latest Publications
- Open Access
- 21 November 2025
- Published by Elsevier in Farmacia Hospitalaria
- Vol. 50 (1) , T64-T66
[Translated article] Contribution of N-oxide metabolite in the therapeutic drug monitoring of voriconazole in a patient with invasive aspergillosis
- 21 November 2025
- Published by Elsevier in Farmacia Hospitalaria
- Vol. 50 (1) , T64-T66
Open Access[Translated article] Contribution of N-oxide metabolite in the therapeutic drug monitoring of voriconazole in a patient with invasive aspergillosis
- Open Access
Optimization of Postoperative Antimicrobial Therapy in Surgical Patients Using a Clinical Decision Support System: Use Patterns and Clinical Outcomes
Background and Objectives: Antimicrobial stewardship plays a key role in the surgical setting by reducing the incidence of healthcare-associated infections and limiting the emergence of antimicrobial resistance. Clinical Decision Support Systems (CDSSs), when integrated into routine practice, are valuable tools for optimizing antimicrobial prescribing. However, evidence regarding their impact on surgical patients, particularly across different specialties, remains limited. Materials and Methods: We conducted a quasi-experimental time series study in surgical patients at a primary-level hospital, evaluating the effect of a CDSS on postoperative antimicrobial therapy. The pre-intervention period included patients admitted from April 2017 to September 2020, and the post-intervention period included those admitted from October 2020 to March 2024. Antimicrobial consumption and expenditures were measured as defined daily doses (DDDs) per 1000 patient-days and euros (€) per 1000 patient-days, respectively. Subgroup analyses were performed by the surgical service. Clinical outcomes included mortality and length of stay (LOS). Results: Following CDSS implementation, overall antimicrobial consumption decreased by 4.4%. Significant reductions were observed in aminoglycosides (−52.0%), macrolides, lincosamides and streptogramins (−40.6%), and fluoroquinolones (−32.3%). Reductions were heterogeneous across surgical services, with significant reductions in Traumatology (−21.3%) and Urology (−14.3%). Expenditures decreased from 3185.4 to 2733.9€/1000 patient-days (−14.2%; p = 0.17). Mortality remained stable, whereas significant reductions in LOS were observed in Urology (5 to 4 days, p = 0.03) and traumatology (16 to 8.5 days, p < 0.01). During the post-intervention period, 476 stewardship recommendations were issued for 330 patients, with an acceptance rate of 76.1%. The most frequent interventions were discontinuation of antimicrobials (25.8%), transition to oral therapy (21.0%), and de-escalation (18.7%). Conclusions: Implementation of a CDSS in the surgical setting was associated with reduced antimicrobial consumption, a downward trend in expenditures, and high acceptance of stewardship recommendations. Mortality remained unchanged, while reductions in LOS in selected services support the safety and potential efficiency of this approach.
Open AccessOptimization of Postoperative Antimicrobial Therapy in Surgical Patients Using a Clinical Decision Support System: Use Patterns and Clinical Outcomes
Background and Objectives: Antimicrobial stewardship plays a key role in the surgical setting by reducing the incidence of healthcare-associated infections and limiting the emergence of antimicrobial resistance. Clinical Decision Support Systems (CDSSs), when integrated into routine practice, are valuable tools for optimizing antimicrobial prescribing. However, evidence regarding their impact on surgical patients, particularly across different specialties, remains limited. Materials and Methods: We conducted a quasi-experimental time series study in surgical patients at a primary-level hospital, evaluating the effect of a CDSS on postoperative antimicrobial therapy. The pre-intervention period included patients admitted from April 2017 to September 2020, and the post-intervention period included those admitted from October 2020 to March 2024. Antimicrobial consumption and expenditures were measured as defined daily doses (DDDs) per 1000 patient-days and euros (€) per 1000 patient-days, respectively. Subgroup analyses were performed by the surgical service. Clinical outcomes included mortality and length of stay (LOS). Results: Following CDSS implementation, overall antimicrobial consumption decreased by 4.4%. Significant reductions were observed in aminoglycosides (−52.0%), macrolides, lincosamides and streptogramins (−40.6%), and fluoroquinolones (−32.3%). Reductions were heterogeneous across surgical services, with significant reductions in Traumatology (−21.3%) and Urology (−14.3%). Expenditures decreased from 3185.4 to 2733.9€/1000 patient-days (−14.2%; p = 0.17). Mortality remained stable, whereas significant reductions in LOS were observed in Urology (5 to 4 days, p = 0.03) and traumatology (16 to 8.5 days, p < 0.01). During the post-intervention period, 476 stewardship recommendations were issued for 330 patients, with an acceptance rate of 76.1%. The most frequent interventions were discontinuation of antimicrobials (25.8%), transition to oral therapy (21.0%), and de-escalation (18.7%). Conclusions: Implementation of a CDSS in the surgical setting was associated with reduced antimicrobial consumption, a downward trend in expenditures, and high acceptance of stewardship recommendations. Mortality remained unchanged, while reductions in LOS in selected services support the safety and potential efficiency of this approach.