Jing Yang

Crystals with elastic and photomechanical properties are rather scarce, but very important. Herein, we report an elastic crystal based on the photo-reactive acylhydrazone derivative (E)-N′-([1,1′-biphenyl]-4-ylmethylene)picolinohydrazide (BPMP). Under ultraviolet (UV) irradiation, the crystal bent away from the UV light. Upon heating, the bent crystal returned to a nearly straight state, demonstrating a reversible bending behavior. The ¹H nuclear magnetic resonance (¹H NMR) data revealed that the molecules in the crystal underwent reversible E ↔ Z isomerization under light and heating conditions. Applying or withdrawing mechanical forces allowed the crystal to be reversibly bent multiple times, displaying excellent elastic properties. Interestingly, the output direction of 635 nm red light could be controlled by controlling the bending of the crystal through light and mechanical force. Therefore, this work provides new ideas for the design of multifunctional elastic crystals.

Allergic bronchopulmonary aspergillosis (ABPA) is an immune-related pulmonary disease caused by sensitization of airway by Aspergillus fumigatus. The disease manifests as bronchial asthma and recurring pulmonary shadows, which may be associated with bronchiectasis. The diagnosis of ABPA mainly depends on serological, immunological, and imaging findings. Pathological examination is not necessary but may be required in atypical cases to exclude pulmonary tuberculosis, tumor, and other diseases through lung biopsy. An 18-year-old man presented with recurrent wheezing, cough, and peripheral blood eosinophilia. Chest computed tomography showed pulmonary infiltration. There was a significant increase in eosinophils in bronchoalveolar lavage fluid. There was no history of residing in a parasite-endemic area or any evidence of parasitic infection. Pathologic examination of bronchoalveolar lavage fluid excluded fungal and mycobacterial infections. The patient was receiving medication for comorbid diseases, but there was no temporal correlation between medication use and clinical manifestations, which excluded drug-induced etiology. Histopathological examination of lung biopsy specimen showed no signs of eosinophilic granulomatosis with polyangiitis, IgG4-related diseases, or tumors. The diagnosis of ABPA was considered based on the history of asthma and the significant increase in serum Aspergillus fumigatus-specific immunoglobulin (Ig)E. Eosinophil-related diseases were excluded through pathological biopsy, which showed typical pathological manifestations of ABPA. The possibility of ABPA should be considered in patients with poorly controlled asthma, especially those with eosinophilia, lung infiltration shadows, or bronchiectasis. Screening for serum IgE, Aspergillus fumigatus-specific IgE and IgG, and alveolar lavage can help avoid misdiagnosis.

Eight MCL Cell lines were cultured for 48 hours in the presence of different concentrations of CFZ. Cell growth was assessed by 3H-thymidine incorporation assay. The IC50 were determined by constructing a dose-response curve. Averages from 3 independent experiments are shown.

Eight MCL Cell lines were cultured for 48 hours in the presence of different concentrations of CFZ. Cell growth was assessed by 3H-thymidine incorporation assay. The IC50 were determined by constructing a dose-response curve. Averages from 3 independent experiments are shown.

PDF - 1267KB, The established MCL cell lines, JVM-2, JVM-13, MAVER, NCEB-1, and Z-138 were treated with 20 nM CFZ for 0, 6, 12, or 24 hours and apoptosis was detected by Annexin V-binding assays. Representative histograms (left panel) and percentages of apoptotic cells (right panel) are shown.

PDF - 1267KB, The established MCL cell lines, JVM-2, JVM-13, MAVER, NCEB-1, and Z-138 were treated with 20 nM CFZ for 0, 6, 12, or 24 hours and apoptosis was detected by Annexin V-binding assays. Representative histograms (left panel) and percentages of apoptotic cells (right panel) are shown.

Article: Membranoproliferative glomerulonephritis with single clone Gigg3-Κ deposition: a case report - Minerva Medica 2022 Mar 10 - Minerva Medica - Journals

Purpose: To report the difference of corneal confocal microscopy examination in patients with preclinical keratoconus or clinical keratoconus. Methods: 8 unilateral keratoconus patients were examined by confocal microscopy before they had cross-linking surgery. As control groups, 23 patients with myopia and 13 patients with keratoconus in both eyes were also examined by confocal microscopy. Then we used Image J to compared the density of epithelium cell, length of cornea nerve fiber, density of Langerhans cell, density of keratocyte in shallow, middle, deep stroma, and the width and grayscale value of fold near Descement membrane for each group. Result: There was differences in corneal epithelial cell count between three groups (4358.27 ± 635.14 cells/mm² versus 4057.81 ± 316.29 cells/mm² versus 3522.65 ± 978.10 cells/mm²). The density of keratocyte in stroma showed a tendency to decrease with increasing depth. The density of keratocyte in keratoconus was less than that in normal eyes. The fold showed much wider and daker in keratoconus eyes than in normal eyes. The density of Langerhans cell was more in keratoconus group than it in normal group. Conclusion: We first report the differences in corneal epithelial cell count and fold near Descement membrane. It might provide a new way to diagnose early keratoconus. The difference of density of Langerhans cell suggested us the possibility of inflammation in keratoconus.