Lan Huang

Supervised by SDG goals (Gender Equality and Quality Education) and renewed national standards, China is performing an ongoing reformation of education curriculum, aiming to eradicate gender discrimination of all kinds—including the omission and stereotyped representation of females in textbooks. To undo the historical preconceptions towards females and build impartial cognition in students, this paper demonstrates a critical approach to exam and refine the acclaimed textbook English (SFP Oxford Edition). The research adopted data collected by Sheng to testify the low participation of female figures in this textbook, and by deep down analyzing the contents of all six textbooks, the prescribed occupation for women, the inadequate representation of motherhood and heroine, and the omission of minority groups have been revealed. This research deconstructed the widely-used textbook in China, raised and categorized problems on equal and precise gender representation, which will guide and facilitate the development and iteration towards ideal textbook.

Chloride ingress in the field structure is influenced by many factors. A non-destructive monitoring is a useful tool for assessing the health of reinforced structures. This study used array sensors to measure the temperature and electrical conductivity of concrete at depths from 10 mm to 140 mm. The electrical conductivity in concrete showed a continuous decrease during the exposure to 3% NaCl solution. A numerical modelling of multi-ion species migration in pore solution can explain the evolution of conductivity profile over exposing time. By comparing with several previous investigations, this study identified the pitfalls in using electrical conductivity or resistivity to monitor the chloride ingress in the exposed concrete. To obtain a correct information from the electrical monitoring system, the experimental and analysing process should consider the saturation degree of concrete, the hydration induced structure change, the leaching of ions, the ingress of chloride and composition of binders.

In aquatic ecosystems, pesticide residues meanly present as mixtures of varying complexity, which may lead to compound pollution of organisms. Therefore, it is of great practical importance to evaluate the combined toxic effects of pesticides. In this study, the mixture acute toxicities of fenvalerate with tebuconazole on zebrafish larvae and adults were investigated. The effects of mixture toxicity on swimming behavior of larvae were also analyzed. The mixture acute toxicity of the systems showed antagonistic effects on adult zebrafish when the mixing ratios of fenvalerate and tebuconazole were equal, but the other two ratios of the mixes both showed synergistic effects. The strongest synergistic effect was observed when fenvalerate was mixed with tebuconazole in the ratio of 8:2. The swimming behavior of zebrafish larvae was significantly inhibited after exposure to single or mixed systems for 2 days. However, significant up-regulation of behavioral indicators in zebrafish larvae was observed at the beginning of exposure in the mixture exposure groups. The results showed that fenvalerate and tebuconazole had the risk of synergistic toxic effect on zebrafish. It is recommended that the simultaneous use of both pesticides in agricultural activities near water bodies should be scientifically controlled to avoid adverse effects on aquatic organisms.

Background: Acute high altitude (HA) exposure elicits blood pressure (BP) responses in most subjects, and some of them suffer from acute mountain sickness (AMS). However, a 24-h ambulatory BP (ABP) change and the correlation with the occurrence of AMS in different sexes are still unclear.Objectives: This prospective study aimed to investigate HA induced BP responses in males and females and the relationship between AMS and 24-h ABP.Methods: Forty-six subjects were matched according to demographic parameters by propensity score matching with a ratio of 1:1. All the subjects were monitored by a 24-h ABP device; the measurement was one period of 24 h BP. 2018 Lake Louise questionnaire was used to evaluate AMS.Results: Both the incidence of AMS (14 [60.9%] vs. 5 [21.7%], P = 0.007) and headache (18 [78.3%] vs. 8 [34.8%], P = 0.003) were higher in females than in males. All subjects showed an elevated BP in the early morning [morning systolic BP (SBP), 114.72 ± 13.57 vs. 120.67 ± 11.10, P = 0.013]. The elevation of morning SBP variation was more significant in females than in males (11.95 ± 13.19 vs. −0.05 ± 14.49, P = 0.005), and a higher morning BP surge increase (4.69 ± 18.09 vs. −9.66 ± 16.96, P = 0.005) was observed after acute HA exposure in the female group. The increase of morning SBP was associated with AMS occurrence (R = 0.662, P < 0.001) and AMS score (R = 0.664, P = 0.001). Among the AMS symptoms, we further revealed that the incidence (R = 0.786, P < 0.001) and the severity of headache (R = 0.864, P < 0.001) are closely correlated to morning SBP.Conclusions: Our study demonstrates that females are more likely to suffer from AMS than males. AMS is closely associated with elevated BP in the early morning period, which may be correlated to higher headache incidence in subjects with higher morning SBP.

Bio-protocol is an online peer-reviewed protocol journal. Its mission is to make life science research more efficient and reproducible by curating and hosting high quality, free access protocols.

Background: Nutrition support is crucial for patients with gastrointestinal (GI) cancer after the operation. However, the controversy over the application of parenteral nutrition (PN) and early enteral immunonutrition (EEIN) has no determinate conclusion. Materials and Methods: We compared the effects of PN and EEIN on the postoperative nutrition condition, immune status, inflammation level, long‐term survival, and quality of life of the patients with GI cancer. Seventy‐eight patients were randomly divided into the PN group (n = 44) or EEIN group (n = 34). After an 8‐day nutrition treatment, clinical and immunological parameters were evaluated. Results: The EEIN group had a significantly shorter hospital stay and higher body mass index level on postoperative day 30 than those in the PN group (P < .05). However, total hospital cost and incidences of short‐term postoperative complications had no significant difference (P > .05). The percentages of CD4⁺, natural killer, and natural killer T lymphocyte cells and the ratio of CD4⁺/CD8⁺ in peripheral blood were significantly increased. Compared with the PN group, the EEIN group had a higher expression of activated cell surface markers such as CD27 and CD28. In addition, the secretion of interleukin (IL)–2 and interferon‐γ was significantly higher, and the secretion of tumor necrosis factor–α and IL‐10 was lower. Complication‐free survival in the EEIN group were longer than those in the PN group (P = .04). Conclusion: EEIN is superior to PN in improving nutrition status, enhancing immune function, and elevating quality of life.

Hypoxic-ischemic encephalopathy (HIE), a serious disease leading to neonatal death, is becoming a key area of pediatric neurological research. Despite remarkable advances in the understanding of HIE, the explicit pathogenesis of HIE is unclear, and well-established treatments are absent. Animal models are usually considered as the first step in the exploration of the underlying disease and in evaluating promising therapeutic interventions. Various animal models of HIE have been developed with distinct characteristics, and it is important to choose an appropriate animal model according to the experimental objectives. Generally, small animal models may be more suitable for exploring the mechanisms of HIE, whereas large animal models are better for translational studies. This review focuses on the features of commonly used HIE animal models with respect to their modeling strategies, merits, and shortcomings, and associated neuropathological changes, providing a comprehensive reference for improving existing animal models and developing new animal models.

Store-operated calcium entry (SOCE), a major mode of extracellular calcium entry, plays roles in a variety of cell activities. Accumulating evidence indicates that the intracellular calcium ion concentration and calcium signaling are critical for the responses induced by oxidative stress. The present study was designed to investigate the potential effect of SOCE inhibition on H2O2-induced apoptosis in endothelial progenitor cells (EPCs), which are the predominant cells involved in endothelial repair. The results showed that H2O2-induced EPC apoptosis was reversed by SOCE inhibition induced either using the SOCE antagonist ML-9 or via silencing of stromal interaction molecule 1 (STIM1), a component of SOCE. Furthermore, SOCE inhibition repressed the increases in intracellular reactive oxygen species (ROS) levels and endoplasmic reticulum (ER) stress and ameliorated the mitochondrial dysfunction caused by H2O2. Our findings provide evidence that SOCE inhibition exerts a protective effect on EPCs in response to oxidative stress induced by H2O2 and may serve as a potential therapeutic strategy against vascular endothelial injury.