Bolaji Fatai Oyeyemi
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Bolaji Fatai Oyeyemi has a total of 17 co-authors. Here are the top co-authors by number of shared publications:
- Aarushi Vasudeva
Department of Zoology, University of Delhi, New Delhi, India
1 shared publication - Anannya Bandyopadhyay
Protein Biology Lab, Room No. 115, Department of Zoology, University of Delhi, Delhi, India
1 shared publication - Anil Chaudhry
Rajan Babu Institute of Pulmonary Medicine and Tuberculosis, New Delhi, India
1 shared publication - Anjali Yadav
Department of Zoology, University of Delhi, New Delhi, India
1 shared publication - Anoop Singh
Department of Zoology, University of Delhi, New Delhi, India
1 shared publication - Arunkumar Malaisamy
Transcription Regulation Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India
1 shared publication
Latest Publications
- 29 November 2025
- Published by Springer Nature in Metabolomics
- Vol. 22 (1) , 1
NMR based human gut metabolomic profiling reveals altered metabolites associated with pulmonary and extra-pulmonary tuberculosis
Introduction Tuberculosis remains one of the world’s deadliest infectious diseases. The pathophysiology of the two manifestations of Mycobacterium tuberculosis infection, pulmonary TB (PTB) and extrapulmonary TB (EPTB) is still not fully understood. Understanding the metabolic profile of both disease manifestations in patients is important for developing therapeutic approaches and molecular diagnosis. Objective The current study aimed to elucidate differences in the gut metabolic profile of PTB and EPTB patients compared to healthy controls (HCs). Method We used an untargeted approach through 1H Nuclear Magnetic Resonance (NMR) spectroscopy to perform metabolomic profiling of stool samples from 77 TB patients [pulmonary TB (PTB, n = 33), cervical lymph node TB (CrLNTB, n = 30), abdominal TB (ATB, n = 14)], and 30 HCs. Multivariate and univariate analyses were performed to identify the differential gut metabolites associated with TB patients. Results PTB patients showed greater metabolic perturbation than either EPTB group, with 24 metabolites significantly altered compared to 13 in ATB and 12 in CrLNTB, relative to HCs (adjusted p < 0.05). Each TB subtype displayed distinct metabolic profiles, yet several metabolites were commonly altered across all TB groups, including valine, N-formyl-L-methionine, choline, dimethylsulfone, tryptophan, valerate, N-acetylglutamate, creatine, and malonate. In the combined TB cohort versus controls, the most discriminatory metabolites were valine and N-formyl-L-methionine (AUC ≥ 0.80). Overall, these findings offer insights into the gut metabolome of TB patients in India and characterize for the first time metabolic perturbations in EPTB patients. Conclusion The study highlights the metabolic disruptions associated with PTB and EPTB patients.
- 29 November 2025
- Published by Springer Nature in Metabolomics
- Vol. 22 (1) , 1
NMR based human gut metabolomic profiling reveals altered metabolites associated with pulmonary and extra-pulmonary tuberculosis
Introduction Tuberculosis remains one of the world’s deadliest infectious diseases. The pathophysiology of the two manifestations of Mycobacterium tuberculosis infection, pulmonary TB (PTB) and extrapulmonary TB (EPTB) is still not fully understood. Understanding the metabolic profile of both disease manifestations in patients is important for developing therapeutic approaches and molecular diagnosis. Objective The current study aimed to elucidate differences in the gut metabolic profile of PTB and EPTB patients compared to healthy controls (HCs). Method We used an untargeted approach through 1H Nuclear Magnetic Resonance (NMR) spectroscopy to perform metabolomic profiling of stool samples from 77 TB patients [pulmonary TB (PTB, n = 33), cervical lymph node TB (CrLNTB, n = 30), abdominal TB (ATB, n = 14)], and 30 HCs. Multivariate and univariate analyses were performed to identify the differential gut metabolites associated with TB patients. Results PTB patients showed greater metabolic perturbation than either EPTB group, with 24 metabolites significantly altered compared to 13 in ATB and 12 in CrLNTB, relative to HCs (adjusted p < 0.05). Each TB subtype displayed distinct metabolic profiles, yet several metabolites were commonly altered across all TB groups, including valine, N-formyl-L-methionine, choline, dimethylsulfone, tryptophan, valerate, N-acetylglutamate, creatine, and malonate. In the combined TB cohort versus controls, the most discriminatory metabolites were valine and N-formyl-L-methionine (AUC ≥ 0.80). Overall, these findings offer insights into the gut metabolome of TB patients in India and characterize for the first time metabolic perturbations in EPTB patients. Conclusion The study highlights the metabolic disruptions associated with PTB and EPTB patients.