Elaine Yeh
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Elaine Yeh has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Andrew T. Atanasiu
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
1 shared publication - Benjamin L. Walker
Department of Mathematics, University of California Irvine, Irvine, CA 92697, USA
1 shared publication - Caitlin Hult
Department of Mathematics, Gettysburg College, Gettysburg, PA 17325, USA
1 shared publication - Daniel Kolbin
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
1 shared publication - Kerry Bloom
The University of North Carolina at Chapel Hill
1 shared publication - Mark Gregory Forest
University of North Carolina at Chapel Hill
1 shared publication
Latest Publications
- Open Access
- 3 December 2025
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 26 (23) , 11697
The Role of Transient Crosslinks in the Chromatin Search Response to DNA Damage
Homology search is a means through which DNA double-strand breaks (DSBs) explore the genome for sequences that enable error-free repair, known as homologous recombination. A better understanding of this search process is fundamental to the relationship between higher-order chromosome organization and DNA damage. Here, we use an entropic bead-spring polymer chain model to simulate the spatiotemporal dynamics of the yeast genome during interphase. The chromosome is organized by transient and dynamic cross-links representing structural maintenance of chromosome (SMC) complexes. DNA damage is modeled as a break in the bead-spring chain, coupled with a removal of crosslinks from beads proximal to the break site. We show that the removal of cross-links drives the exploration of genomic space by the damaged ends, while rates and densities of intact dynamic crosslinking have only a minor role. Local depletion of SMC cross-links proximal to the break site enables the damaged segment to escape the chromosome territory and enhances its ability to explore the genome. Our study reveals a foundational principle by which DSBs can encounter distant regions of sequence homology.
- 3 December 2025
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 26 (23) , 11697
Open AccessThe Role of Transient Crosslinks in the Chromatin Search Response to DNA Damage
Homology search is a means through which DNA double-strand breaks (DSBs) explore the genome for sequences that enable error-free repair, known as homologous recombination. A better understanding of this search process is fundamental to the relationship between higher-order chromosome organization and DNA damage. Here, we use an entropic bead-spring polymer chain model to simulate the spatiotemporal dynamics of the yeast genome during interphase. The chromosome is organized by transient and dynamic cross-links representing structural maintenance of chromosome (SMC) complexes. DNA damage is modeled as a break in the bead-spring chain, coupled with a removal of crosslinks from beads proximal to the break site. We show that the removal of cross-links drives the exploration of genomic space by the damaged ends, while rates and densities of intact dynamic crosslinking have only a minor role. Local depletion of SMC cross-links proximal to the break site enables the damaged segment to escape the chromosome territory and enhances its ability to explore the genome. Our study reveals a foundational principle by which DSBs can encounter distant regions of sequence homology.