Sviatoslav Ohiienko

Introduction. The increasing resistance of Candida species to conventional antifungal agents necessitates the development of alternative therapies, especially in dentistry. This study aims to assess the antifungal activity of hydroethanolic extracts from aromatic plants against Candida albicans and non-albicans species isolated from oral mucosal swabs of patients with oral candidiasis. Methods. Thirteen plant extracts—laurel (Laurus nobilis L.), dwarf rosemary (Rosmarinus officinalis L.), ginger (Zingiber officinale Roscoe), turmeric (Curcuma longa L.), cinnamon bark (Ceylon Cinnamon) (Cinnamomum verum J. Presl), sweet basil (Ocimum basilicum L.), creeping thyme (Thymus serpyllum L.), wild marjoram (Oregano) (Origanum vulgare L.), tarragon (Artemisia dracunculus L.), black pepper (Piper nigrum L.), coriander (Coriandrum sativum L.), nutmeg (Myristica fragrans Houtt.), and chili pepper (Capsicum frutescens L.)—were prepared using 90% ethanol and tested against five clinical Candida strains (C. albicans, C. tropicalis, C. lusitaniae, C. kefyr, C. lipolytica) using the agar diffusion method. Fluconazole, chlorhexidine, decamethoxine, Stomatophyte, and Recutan served as control agents. Results. Fluconazole showed the highest activity against all Candida spp. Among plant extracts, nutmeg and coriander were comparable to fluconazole in their activity against C. tropicalis. Creeping thyme and chili pepper exhibited broad-spectrum moderate activity against multiple strains, occasionally matching or surpassing the efficacy of decamethoxine and chlorhexidine. No plant extract demonstrated sufficient activity against C. lusitaniae. Conclusions. A preliminary in vitro assessment of plant extracts, particularly nutmeg, coriander, creeping thyme, and chili pepper, showed promising antifungal activity against this limited panel of clinical isolates.

Aim: Our aim was to identify the markers necessary to predict the probability of alveolitis in case of tooth extraction under the conditions of a clinical laboratory and within the workplace of a dental surgeon. Material and methods: 160 patients were under our supervision. Since men and women may undergo tooth extractions throughout their lives, we selected adult patients (from 18 to 75 years old) including 100 men and 60 women. Results: According to the results of our research, OHI indicators, which were conducted for 14 days, showed that the average statistical value of OHI constituted (2.01±0.11) points the day after the extraction in Group II in case of scheduled tooth extraction corresponding to indicators of a satisfactory state of hygiene. Conclusions: 1. The inclusion of pectin-containing medication in the complex of preventive measures is fully justified in relation to the occurrence of inflammatory complications after tooth extractions in modern conditions of a doctor’s work at an outpatient clinic. 2. The wound surface of the socket of the extracted tooth should be covered with a bandage. 3. Under the conditions of a clinical laboratory and within a workplace of a dental surgeon, the markers necessary to predict the probability of alveolitis in case of a tooth extraction are the following: clinical indicators of normalization of the oral cavity hygienic state, a significant decrease in the intensity and prevalence of the inflammatory process in the gums, changes in the oral fluid pH towards the alkaline side.