Patrick Neubert
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Patrick Neubert has a total of 27 co-authors. Here are the top co-authors by number of shared publications:
Agnes Schröder
Department of Orthodontics, University Hospital Regensburg, Regensburg, Germany
1 shared publication- Ann-Kathrin Baumgart
Institute for Molecular Medicine and Experimental Immunology, University of Bonn, Bonn, Germany
1 shared publication - Annkristin Heine
Division of Hematology Medical University of Graz Graz Austria
1 shared publication - Christian Kurts
Institute of Molecular Medicine and Experimental Immunology, University Hospital Bonn, Germany
1 shared publication - Christian Münch
Goethe University Frankfurt
1 shared publication - Christoph Heuser-Loy
Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany
1 shared publication
Latest Publications
- Open Access
- 20 December 2025
- Published by Springer Nature in Cell Death & Disease
- Vol. 17 (1)
High-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma
High salt diet (HSD) is known to reduce cancer growth in some tumor models, which has been attributed to tissue accumulation of sodium that enhances local anti-tumor immunity. Here, we show that a HSD inhibits melanoma growth independent of sodium accumulation and immune cells in skin and lung. Melanoma cells from mice on a HSD upregulated the metabolic inhibitor Tuberous sclerosis complex 2 (TSC2), causing metabolic shutdown despite nutrient availability. Furthermore, Microphthalmia-associated transcription factor (MITF), a crucial regulator of melanoma metabolism and differentiation, was upregulated, resulting in enhanced melanogenesis and cell cycle arrest. Thus, a HSD reversed the de-differentiation of melanoma cells and promoted their re-differentiation into a “normal” melanocytic state. These findings suggest that the anti-tumor effect of HSD may be tumor-specific and in some cases immune cell-independent.
- 20 December 2025
- Published by Springer Nature in Cell Death & Disease
- Vol. 17 (1)
Open AccessHigh-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma
High salt diet (HSD) is known to reduce cancer growth in some tumor models, which has been attributed to tissue accumulation of sodium that enhances local anti-tumor immunity. Here, we show that a HSD inhibits melanoma growth independent of sodium accumulation and immune cells in skin and lung. Melanoma cells from mice on a HSD upregulated the metabolic inhibitor Tuberous sclerosis complex 2 (TSC2), causing metabolic shutdown despite nutrient availability. Furthermore, Microphthalmia-associated transcription factor (MITF), a crucial regulator of melanoma metabolism and differentiation, was upregulated, resulting in enhanced melanogenesis and cell cycle arrest. Thus, a HSD reversed the de-differentiation of melanoma cells and promoted their re-differentiation into a “normal” melanocytic state. These findings suggest that the anti-tumor effect of HSD may be tumor-specific and in some cases immune cell-independent.