Firdevs Demirel
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Firdevs Demirel has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Ali Asram Sağıroğlu
Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University-Cerrahpasa
1 shared publication - Aysenur Gunaydin Akyildiz
Istanbul University-Cerrahpasa
1 shared publication - Beyza Sumeyye Aydin
Health Sciences Institute, Bezmialem Vakif University, 34093 Istanbul, Turkey
1 shared publication - Gülaçtı Topçu
Bezmialem Vakif University
1 shared publication - Gülbahar Özge Alim Toraman
Department of Pharmacognosy, Faculty of Pharmacy, Bezmialem Vakif University
1 shared publication - Zehra Keskin
Institute of Graduate Studies in Health Sciences, Istanbul University , Bozdogan Kemeri Avenue No. 4, 34126 Fatih
1 shared publication
Latest Publications
- Open Access
- 23 December 2025
- Published by MDPI AG in Pharmaceuticals
- Vol. 19 (1) , 32
Development and Evaluation of Platanus orientalis L. Extract-Loaded Liposomes for Enhanced Wound Healing
Background/Objectives: Wound healing is a complex biological process influenced by inflammation, oxidative stress, and cellular regeneration. Plant-derived bioactive compounds have shown potential to accelerate tissue repair through antioxidant and anti-inflammatory mechanisms. This study aimed to develop and evaluate a Platanus orientalis extract-loaded liposomal formulation for potential wound-healing applications. Methods: Four polar extracts (P1–P4) were prepared using different solvent systems and extraction techniques and were characterized by LC-HRMS to determine their phytochemical profiles. Among the identified constituents, quercetin was consistently detected across all extracts and selected as the reference compound due to its well-known wound-healing activity. Liposomes were prepared via thin-film hydration followed by probe sonication and characterized for particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, and total drug content. In vitro release, cytotoxicity, and wound-healing assays were subsequently conducted to assess performance. Results: The optimized liposome formulation had a mean particle size of 106.6 ± 5.4 nm, a PDI of 0.11 ± 0.04, and a zeta potential of −14.1 ± 0.5 mV. Environmental scanning electron microscopy (ESEM) confirmed the nanosized spherical morphology and homogeneous vesicle distribution, supporting the successful development of the liposomal delivery system. Encapsulation efficiency and total drug content were determined as 72.25 ± 1.05% and 96.15 ± 0.14%, respectively. In vitro release studies demonstrated a biphasic pattern with an initial burst followed by a sustained release, reaching approximately 75% cumulative quercetin release within 24 h. Physical stability testing confirmed that the optimized liposomal formulation remained physically stable at 5 ± 3 °C for at least 60 days. The optimized formulation showed no cytotoxic effects on CDD-1079Sk fibroblast cells and exhibited significantly enhanced wound closure in vitro. Conclusions: These findings indicate that the liposomal delivery of Platanus orientalis extract provides a biocompatible and sustained-release system that enhances wound-healing efficacy, supporting its potential use in advanced topical therapeutic applications.
- 23 December 2025
- Published by MDPI AG in Pharmaceuticals
- Vol. 19 (1) , 32
Open AccessDevelopment and Evaluation of Platanus orientalis L. Extract-Loaded Liposomes for Enhanced Wound Healing
Background/Objectives: Wound healing is a complex biological process influenced by inflammation, oxidative stress, and cellular regeneration. Plant-derived bioactive compounds have shown potential to accelerate tissue repair through antioxidant and anti-inflammatory mechanisms. This study aimed to develop and evaluate a Platanus orientalis extract-loaded liposomal formulation for potential wound-healing applications. Methods: Four polar extracts (P1–P4) were prepared using different solvent systems and extraction techniques and were characterized by LC-HRMS to determine their phytochemical profiles. Among the identified constituents, quercetin was consistently detected across all extracts and selected as the reference compound due to its well-known wound-healing activity. Liposomes were prepared via thin-film hydration followed by probe sonication and characterized for particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, and total drug content. In vitro release, cytotoxicity, and wound-healing assays were subsequently conducted to assess performance. Results: The optimized liposome formulation had a mean particle size of 106.6 ± 5.4 nm, a PDI of 0.11 ± 0.04, and a zeta potential of −14.1 ± 0.5 mV. Environmental scanning electron microscopy (ESEM) confirmed the nanosized spherical morphology and homogeneous vesicle distribution, supporting the successful development of the liposomal delivery system. Encapsulation efficiency and total drug content were determined as 72.25 ± 1.05% and 96.15 ± 0.14%, respectively. In vitro release studies demonstrated a biphasic pattern with an initial burst followed by a sustained release, reaching approximately 75% cumulative quercetin release within 24 h. Physical stability testing confirmed that the optimized liposomal formulation remained physically stable at 5 ± 3 °C for at least 60 days. The optimized formulation showed no cytotoxic effects on CDD-1079Sk fibroblast cells and exhibited significantly enhanced wound closure in vitro. Conclusions: These findings indicate that the liposomal delivery of Platanus orientalis extract provides a biocompatible and sustained-release system that enhances wound-healing efficacy, supporting its potential use in advanced topical therapeutic applications.