Caroline Merwin
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Caroline Merwin has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Attila Molvarec
Department of Obstetrics and Gynecology, Semmelweis University, 1085 Budapest, Hungary
1 shared publication - Edina Amalia Wappler-Guzzetta
Department of Pathology and Laboratory Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
1 shared publication - Eva Margittai
Institute of Clinical Pathophysiology, Semmelweis University, 1085 Budapest, Hungary
1 shared publication - Ibolya Czegle
Department of Internal Medicine and Hematology, Semmelweis University, 1085 Budapest, Hungary
1 shared publication - Krisztina Veszelyi
Institute of Translational Medicine, Semmelweis University, 1085 Budapest, Hungary
1 shared publication - Shanel C. Pickard
Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
1 shared publication
Latest Publications
- Open Access
- 28 December 2025
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 27 (1) , 342
Subcellular Stress Markers in Epithelial Ovarian Cancer
Epithelial ovarian cancer is one of the most lethal gynecological malignancies worldwide. Its development strongly depends on several genetic and environmental factors, with metabolic components and cellular redox homeostasis alterations playing a significant a role in its development and disease progression. In this review, we summarize the contribution of mitochondrial and endoplasmic reticulum (ER) stress in the pathogenesis of epithelial ovarian cancer along with their role as potential biomarkers and therapeutic targets, including proteins of glucose metabolism, mitochondrial fission and fusion, mitophagy, membrane-associated ring-CH-type finger 5 (MARCH5), A-kinase anchoring proteins (AKAPs), proteins regulating mitochondrial Ca2+ homeostasis, mitochondrial unfolded protein response (UPRmt) proteins, activating transcription factors (ATFs), CCAAT enhancer binding protein (C/EBP) homologous protein (CHOP), ‘mitokines’, GRP75, and GRP78. Although many of these potential targets are in preclinical phase, they have a high potential to become valuable alternative or additive treatments for epithelial ovarian cancers.
- 28 December 2025
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 27 (1) , 342
Open AccessSubcellular Stress Markers in Epithelial Ovarian Cancer
Epithelial ovarian cancer is one of the most lethal gynecological malignancies worldwide. Its development strongly depends on several genetic and environmental factors, with metabolic components and cellular redox homeostasis alterations playing a significant a role in its development and disease progression. In this review, we summarize the contribution of mitochondrial and endoplasmic reticulum (ER) stress in the pathogenesis of epithelial ovarian cancer along with their role as potential biomarkers and therapeutic targets, including proteins of glucose metabolism, mitochondrial fission and fusion, mitophagy, membrane-associated ring-CH-type finger 5 (MARCH5), A-kinase anchoring proteins (AKAPs), proteins regulating mitochondrial Ca2+ homeostasis, mitochondrial unfolded protein response (UPRmt) proteins, activating transcription factors (ATFs), CCAAT enhancer binding protein (C/EBP) homologous protein (CHOP), ‘mitokines’, GRP75, and GRP78. Although many of these potential targets are in preclinical phase, they have a high potential to become valuable alternative or additive treatments for epithelial ovarian cancers.