Najima Ahmed
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Najima Ahmed has a total of 2 co-authors. Here are the top co-authors by number of shared publications:
- Ramesh Chandra Deka
Tezpur University
2 shared publications - Suvendra Kumar Ray
Tezpur University
2 shared publications
Latest Publications
- 1 May 2026
- Published by Springer Nature in Resonance
- Vol. 31 (5) , 637-650
Vitamin C: A Journey from Discovery to Antioxidative Significance
- 1 May 2026
- Published by Springer Nature in Resonance
- Vol. 31 (5) , 637-650
Vitamin C: A Journey from Discovery to Antioxidative Significance
- Open Access
- 28 December 2025
- Published by Tezpur University in Multidisciplinary Research Journal
- p. 60-72
DNA Damage Induced by Alcoholic Beverages and Repair Mechanism Pathways: A Review
Alcoholic beverages contains ethanol as the main component. Ethanol is metabolized into acetaldehyde, a Group 1 carcinogen, and other reactive by-products such as ROS and hydroxyl radicals. These metabolites can interact with DNA to form adducts and interstrand cross-links, leading to mutations and genomic instability, which are key contributors to alcohol-related cancers. Ethanol metabolism is mediated by critical enzymes - Alcohol Dehydrogenase (ADH), Cytochrome P450 2E1 (CYP2E1), Catalase, and Aldehyde Dehydrogenase (ALDH), which regulate both the generation and detoxification of these harmful intermediates. Every cell in our body owns a toolkit with which it can repair different types of DNA lesions. This review highlights the enzymatic pathways of ethanol metabolism, the formation of genotoxic by-products, and the cellular mechanisms that maintain genomic integrity. Understanding these processes provides crucial insights into the molecular basis of alcohol-induced carcinogenesis and may guide strategies for prevention and therapeutic intervention.
- 28 December 2025
- Published by Tezpur University in Multidisciplinary Research Journal
- p. 60-72
Open AccessDNA Damage Induced by Alcoholic Beverages and Repair Mechanism Pathways: A Review
Alcoholic beverages contains ethanol as the main component. Ethanol is metabolized into acetaldehyde, a Group 1 carcinogen, and other reactive by-products such as ROS and hydroxyl radicals. These metabolites can interact with DNA to form adducts and interstrand cross-links, leading to mutations and genomic instability, which are key contributors to alcohol-related cancers. Ethanol metabolism is mediated by critical enzymes - Alcohol Dehydrogenase (ADH), Cytochrome P450 2E1 (CYP2E1), Catalase, and Aldehyde Dehydrogenase (ALDH), which regulate both the generation and detoxification of these harmful intermediates. Every cell in our body owns a toolkit with which it can repair different types of DNA lesions. This review highlights the enzymatic pathways of ethanol metabolism, the formation of genotoxic by-products, and the cellular mechanisms that maintain genomic integrity. Understanding these processes provides crucial insights into the molecular basis of alcohol-induced carcinogenesis and may guide strategies for prevention and therapeutic intervention.