Hyelin Jeon
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Hyelin Jeon has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Dae Soo Lim
Daedeok Pharma Co., Ltd., Suwon 16229, Republic of Korea
1 shared publication - Jeongjin Park
Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Republic of Korea
1 shared publication - Minhee Lee
Department of Food Innovation and Health, Kyung Hee University, Yongin 17104, Republic of Korea
1 shared publication - Wonhee Cho
Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Republic of Korea
1 shared publication - Woojin Jun
Division of Food and Nutrition, Chonnam National University
1 shared publication - Yeonhwa Lee
Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Republic of Korea
1 shared publication
Latest Publications
- Open Access
- 30 December 2025
- Published by MDPI AG in Current Issues in Molecular Biology
- Vol. 48 (1) , 50
Broccoli Extract (Broccoli NMN®) Improves Skin Hydration by Regulating HAS and NF-κB Pathways and Reduces Wrinkle Formation via the TGF-βR1/Smad3/Collagen Pathway
This study investigated the effects and mechanisms of broccoli extract containing more than 99.0% β-NMN (BRC) on UVB-induced skin damage, including moisture loss, oxidative stress, inflammation, wrinkle formation, and melanin production, using in vitro and in vivo models. BRC treatment significantly alleviated UVB-induced skin dehydration, oxidative stress, and inflammatory responses, as well as inhibited wrinkle formation and melanin synthesis. Mechanistically, BRC enhanced skin hydration and barrier function by upregulating hyaluronic acid synthases and genes related to sphingolipid metabolism, while simultaneously suppressing NF-κB signaling and COX-2 expression, thereby re-ducing inflammation. Moreover, BRC promoted collagen synthesis by activating the TGF-βR1/Smad3/Collagen pathway and prevented extracellular matrix degradation by inhibiting JNK/c-Fos/c-Jun/MMPs signaling. In addition, BRC modulated the cAMP/PKA/CREB/MITF/TRPs pathway, leading to reduced melanin production. These findings suggest that BRC supplementation may effectively protect against UVB-induced skin damage, supporting its potential application as a functional ingredient for skin health.
- 30 December 2025
- Published by MDPI AG in Current Issues in Molecular Biology
- Vol. 48 (1) , 50
Open AccessBroccoli Extract (Broccoli NMN®) Improves Skin Hydration by Regulating HAS and NF-κB Pathways and Reduces Wrinkle Formation via the TGF-βR1/Smad3/Collagen Pathway
This study investigated the effects and mechanisms of broccoli extract containing more than 99.0% β-NMN (BRC) on UVB-induced skin damage, including moisture loss, oxidative stress, inflammation, wrinkle formation, and melanin production, using in vitro and in vivo models. BRC treatment significantly alleviated UVB-induced skin dehydration, oxidative stress, and inflammatory responses, as well as inhibited wrinkle formation and melanin synthesis. Mechanistically, BRC enhanced skin hydration and barrier function by upregulating hyaluronic acid synthases and genes related to sphingolipid metabolism, while simultaneously suppressing NF-κB signaling and COX-2 expression, thereby re-ducing inflammation. Moreover, BRC promoted collagen synthesis by activating the TGF-βR1/Smad3/Collagen pathway and prevented extracellular matrix degradation by inhibiting JNK/c-Fos/c-Jun/MMPs signaling. In addition, BRC modulated the cAMP/PKA/CREB/MITF/TRPs pathway, leading to reduced melanin production. These findings suggest that BRC supplementation may effectively protect against UVB-induced skin damage, supporting its potential application as a functional ingredient for skin health.