Duran Ramsuran
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Duran Ramsuran has a total of 28 co-authors. Here are the top co-authors by number of shared publications:
- Alasdair Leslie
Africa Health Research Institute, Durban, South Africa
1 shared publication - Alex K. Shalek
Institute for Medical Engineering and Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
1 shared publication - Andries J. C. Steyn
Africa Health Research Institute, Durban, South Africa
1 shared publication - Bonnie Berger
Massachusetts Institute of Technology
1 shared publication - Farina Karim
Africa Health Research Institute , Durban, South Africa
1 shared publication - Henrik N. Kloverpris
African Health Research Institute , Durban
1 shared publication
Latest Publications
- Top Cited PapersOpen Access
- 5 January 2026
- Published by Rockefeller University Press in Journal of Experimental Medicine
- Vol. 223 (3)
Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology
Tuberculosis (TB) typically causes lung destruction and fibrosis, leading to ∼1.3 million deaths annually. The cellular drivers of human TB immunopathology remain poorly defined. We performed single-cell RNA sequencing and spatial transcriptomics on lung tissues from TB-infected and TB-negative individuals, identifying 30 distinct immune, parenchymal, and stromal cell subsets. Several were linked to TB pathology and corroborated through immunohistochemistry, flow cytometry, and independent human datasets. Fibroblasts were identified as major drivers in both active TB granuloma and TB-diseased lung tissue. In particular, the MMP1+CXCL5+ fibroblast subset, expressing a myofibroblast-like gene signature, was associated with severe disease and higher bacterial burden in nonhuman primate granulomas. Network analyses revealed cross talk between MMP1+CXCL5+ fibroblasts and SPP1+ macrophages within the granuloma cuff, which has been reported in other disease contexts, and may play an important role in TB immunopathology. Our findings highlight previously unappreciated cell populations and potential targets for novel TB therapies.
- 5 January 2026
- Published by Rockefeller University Press in Journal of Experimental Medicine
- Vol. 223 (3)
Top Cited PapersOpen AccessSingle-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology
Tuberculosis (TB) typically causes lung destruction and fibrosis, leading to ∼1.3 million deaths annually. The cellular drivers of human TB immunopathology remain poorly defined. We performed single-cell RNA sequencing and spatial transcriptomics on lung tissues from TB-infected and TB-negative individuals, identifying 30 distinct immune, parenchymal, and stromal cell subsets. Several were linked to TB pathology and corroborated through immunohistochemistry, flow cytometry, and independent human datasets. Fibroblasts were identified as major drivers in both active TB granuloma and TB-diseased lung tissue. In particular, the MMP1+CXCL5+ fibroblast subset, expressing a myofibroblast-like gene signature, was associated with severe disease and higher bacterial burden in nonhuman primate granulomas. Network analyses revealed cross talk between MMP1+CXCL5+ fibroblasts and SPP1+ macrophages within the granuloma cuff, which has been reported in other disease contexts, and may play an important role in TB immunopathology. Our findings highlight previously unappreciated cell populations and potential targets for novel TB therapies.