Idrus Alwi
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Idrus Alwi has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Alida Roswita Harahap
Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
1 shared publication - Arif Mansjoer
Divisi Kardiologi Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo Jakarta
1 shared publication - Dita Aditianingsih
Universitas Indonesia - Cipto Mangunkusumo National General Hospital
1 shared publication - Dudy Arman Hanafy
University of Indonesia
1 shared publication - Em Yunir
Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
1 shared publication - Kuntjoro Harimurti
Division of Geriatrics, Department of Internal Medicine, Cipto Mangunkusumo Hospital - Faculty of Medicine Universitas Indonesia, Central Jakarta, Indonesia.
1 shared publication
Latest Publications
- 1 October 2025
- Vol. 57 (4) , 493-502
Temporal Changes in Inflammation, Oxidative Stress, Apoptosis, and Endothelial Glycocalyx Degradation in Correlation to Organ Function Assessment Following On-Pump Coronary Artery Bypass Graft Surgery.
A coronary artery bypass graft is a complex procedure that can cause various physiological responses, including inflammation, oxidative stress, apoptosis, and endothelial dysfunction. Nevertheless, the correlation between these responses and organ function after CABG has not yet been established. This study aims to investigate the correlation between inflammation, oxidative stress, apoptosis, endothelial dysfunction markers, and postoperative organ function assessment as evaluated by the Cardiac Surgery Score (CASUS). A prospective cohort study was conducted on patients undergoing coronary artery bypass graft from two hospitals in Jakarta. IL-6, MDA, caspase-3, and syndecan-1 levels were measured at three points in time: before surgery, on ICU Day-1, and ICU Day-2. Postoperative organ function was assessed on ICU Day 2 by Cardiac Surgery Score (CASUS). Fifty-one patients were included in the study. There was a positive correlation between IL-6 measured before surgery (r = 0.325, p = 0.020) and at the time of admission to the ICU (r = 0.374, p = 0.007). Positive correlation was also found between syndecan-1 levels on ICU day 1 (r = 0.304, p = 0.030) with CASUS. MDA correlated with CASUS on ICU day 2 (r = 0.392, p = 0.004); meanwhile, no significant association was found between caspase-3 and postoperative organ function assessment. Interleukin-6 levels pre-surgery and on ICU day 1, syndecan-1 levels on ICU day 1, and MDA levels on ICU day 2 were correlated with CASUS.
- 1 October 2025
- Vol. 57 (4) , 493-502
Temporal Changes in Inflammation, Oxidative Stress, Apoptosis, and Endothelial Glycocalyx Degradation in Correlation to Organ Function Assessment Following On-Pump Coronary Artery Bypass Graft Surgery.
A coronary artery bypass graft is a complex procedure that can cause various physiological responses, including inflammation, oxidative stress, apoptosis, and endothelial dysfunction. Nevertheless, the correlation between these responses and organ function after CABG has not yet been established. This study aims to investigate the correlation between inflammation, oxidative stress, apoptosis, endothelial dysfunction markers, and postoperative organ function assessment as evaluated by the Cardiac Surgery Score (CASUS). A prospective cohort study was conducted on patients undergoing coronary artery bypass graft from two hospitals in Jakarta. IL-6, MDA, caspase-3, and syndecan-1 levels were measured at three points in time: before surgery, on ICU Day-1, and ICU Day-2. Postoperative organ function was assessed on ICU Day 2 by Cardiac Surgery Score (CASUS). Fifty-one patients were included in the study. There was a positive correlation between IL-6 measured before surgery (r = 0.325, p = 0.020) and at the time of admission to the ICU (r = 0.374, p = 0.007). Positive correlation was also found between syndecan-1 levels on ICU day 1 (r = 0.304, p = 0.030) with CASUS. MDA correlated with CASUS on ICU day 2 (r = 0.392, p = 0.004); meanwhile, no significant association was found between caspase-3 and postoperative organ function assessment. Interleukin-6 levels pre-surgery and on ICU day 1, syndecan-1 levels on ICU day 1, and MDA levels on ICU day 2 were correlated with CASUS.