Yasmin Cometti Sardinha
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Yasmin Cometti Sardinha has a total of 10 co-authors. Here are the top co-authors by number of shared publications:
- Aislan Cristina Rheder Fagundes Pascoal
Research Laboratory of Natural Products and Bioactive Molecules, (Lab Nat—UFF) Nova Friburgo Health Institute, Fluminense Federal University—UFF, Nova Friburgo 28625-650, RJ, Brazil
1 shared publication - Francisco Paiva Machado
Laboratory of Natural Products Technology, Department of Pharmaceutical Technology, School of Pharmacy, Fluminense Federal University, Niterói 24241-000, RJ, Brazil
1 shared publication - Kaique Gonçalves de Souza
Research Laboratory of Natural Products and Bioactive Molecules, (Lab Nat—UFF) Nova Friburgo Health Institute, Fluminense Federal University—UFF, Nova Friburgo 28625-650, RJ, Brazil
1 shared publication - Kevin Costa Miranda
Laboratory of Natural Products Technology, Department of Pharmaceutical Technology, School of Pharmacy, Fluminense Federal University, Niterói 24241-000, RJ, Brazil
1 shared publication - Larissa Saviani Ribeiro
Research Laboratory of Natural Products and Bioactive Molecules, (Lab Nat—UFF) Nova Friburgo Health Institute, Fluminense Federal University—UFF, Nova Friburgo 28625-650, RJ, Brazil
1 shared publication - Leandro Rocha
Laboratory of Natural Products Technology, Department of Pharmaceutical Technology, School of Pharmacy, Fluminense Federal University, Niterói 24241-000, RJ, Brazil
1 shared publication
Latest Publications
- Open Access
Chemical Profiling and Multimodal Anti-Inflammatory Activity of Eugenia pyriformis Leaves Essential Oil
Eugenia pyriformis Cambess., popularly known as uvaia, is a native Brazilian species belonging to the Myrtaceae family that has attracted pharmacological interest due to its richness in bioactive secondary metabolites. Previous studies have reported antimicrobial and antioxidant activities of the essential oil obtained from its leaves, reinforcing its therapeutic potential. In this context, the present study aimed to extract and characterize the essential oil from E. pyriformis leaves cultivated in the mountainous region of Rio de Janeiro, Brazil, and to evaluate its anti-inflammatory potential through in vitro and in vivo models. Gas chromatography mass spectrometry (GC–MS) analysis revealed a predominance of sesquiterpene hydrocarbons, mainly γ-muurolene, δ-cadinene, and β-caryophyllene. The oil exhibited significant anti-edematogenic activity in carrageenan-, prostaglandin E2-, and bradykinin-induced paw edema models in adult female Swiss mice, suggesting modulation of inflammatory mediators, possibly through inhibition of the cyclooxygenase (COX) pathway. Conversely, no effect was observed in the compound 48/80-induced model, indicating the absence of activity on histamine- and serotonin-mediated processes. In vitro assays demonstrated that the oil reduced TNF-α and IL-1β gene expression in RAW 264.7 macrophages, confirming its ability to modulate pro-inflammatory cytokines. Taken together, these findings demonstrate that the essential oil of E. pyriformis exerts anti-inflammatory activity through multiple targets.
Open AccessChemical Profiling and Multimodal Anti-Inflammatory Activity of Eugenia pyriformis Leaves Essential Oil
Eugenia pyriformis Cambess., popularly known as uvaia, is a native Brazilian species belonging to the Myrtaceae family that has attracted pharmacological interest due to its richness in bioactive secondary metabolites. Previous studies have reported antimicrobial and antioxidant activities of the essential oil obtained from its leaves, reinforcing its therapeutic potential. In this context, the present study aimed to extract and characterize the essential oil from E. pyriformis leaves cultivated in the mountainous region of Rio de Janeiro, Brazil, and to evaluate its anti-inflammatory potential through in vitro and in vivo models. Gas chromatography mass spectrometry (GC–MS) analysis revealed a predominance of sesquiterpene hydrocarbons, mainly γ-muurolene, δ-cadinene, and β-caryophyllene. The oil exhibited significant anti-edematogenic activity in carrageenan-, prostaglandin E2-, and bradykinin-induced paw edema models in adult female Swiss mice, suggesting modulation of inflammatory mediators, possibly through inhibition of the cyclooxygenase (COX) pathway. Conversely, no effect was observed in the compound 48/80-induced model, indicating the absence of activity on histamine- and serotonin-mediated processes. In vitro assays demonstrated that the oil reduced TNF-α and IL-1β gene expression in RAW 264.7 macrophages, confirming its ability to modulate pro-inflammatory cytokines. Taken together, these findings demonstrate that the essential oil of E. pyriformis exerts anti-inflammatory activity through multiple targets.