Hong Zhang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Hong Zhang has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
- Bin Gong
Pinglu Canal and Beibu Gulf Coastal Ecosystem Observation and Research Station of Guangxi, Guangxi Key Laboratory of Marine Environmental Disaster Processes and Ecological Protection Technology, College of Marine Sciences Beibu Gulf University Qinzhou China
1 shared publication - Cheng Huang
Guangxi Key Laboratory of Marine Environmental Disaster Processes and Ecological Protection Technology, Beibu Gulf Marine Ecological Environment Field Observation and Research Station of Guangxi, College of Marine Sciences, Beibu Gulf University, Qinzhou 535011, China
1 shared publication - Da Zeng
Guangxi Key Laboratory of Marine Environmental Disaster Processes and Ecological Protection Technology, Beibu Gulf Marine Ecological Environment Field Observation and Research Station of Guangxi, College of Marine Sciences, Beibu Gulf University, Qinzhou 535011, China
1 shared publication - Laiba Shafique
Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation, Pinglu Canal and Beibu Gulf Coastal Ecosystem Observation and Research Station of Guangxi, Beibu Gulf University, Qinzhou, China
1 shared publication - Li Li
Guangxi Key Laboratory of Marine Environmental Disaster Processes and Ecological Protection Technology, Beibu Gulf Marine Ecological Environment Field Observation and Research Station of Guangxi, College of Marine Sciences, Beibu Gulf University, Qinzhou 535011, China
1 shared publication - Muhammad Farhan Khan
Department of Chemistry, Gomal University, Dera Ismail Khan 29050, Pakistan
1 shared publication
Latest Publications
- Open Access
A Conserved Bactericidal Permeability-Increasing Protein (BPI) Mediates Immune Sensing and Host Defense in the Hong Kong Oyster (Crassostrea hongkongensis)
The bactericidal permeability-increasing protein (BPI) and lipopolysaccharide binding protein (LBP) are fundamental to innate immunity. However, their functional diversity and evolutionary conservation in ecologically crucial invertebrates, such as oysters, remain largely understudied. In this study, we identify and characterize a novel homolog of BPI/LBP, designated as ChBPI/LBP in the Hong Kong oyster (Crassostrea hongkongensis). Through structural and phylogenetic analysis, we identify ChBPI/LBP as a distinct member of the BPI protein family, with a high isoelectric point (pI of 9.26), indicating potent cationic BPI-like bactericidal function. We found that ChBPI/LBP is constitutively highly expressed at mucosal sites such as the gills and is rapidly upregulated in hemocytes following a challenge with Aeromonas hydrophila. Recombinant ChBPI/LBP demonstrated potent and specific bactericidal activity against Gram-negative pathogens. These findings suggest that ChBPI/LBP is an important antimicrobial peptide (AMP) effector in the oyster’s immune response. This work provides novel perspectives on the evolutionary mechanisms of innate immunity in bivalves and may have implications for disease management in aquaculture.
Open AccessA Conserved Bactericidal Permeability-Increasing Protein (BPI) Mediates Immune Sensing and Host Defense in the Hong Kong Oyster (Crassostrea hongkongensis)
The bactericidal permeability-increasing protein (BPI) and lipopolysaccharide binding protein (LBP) are fundamental to innate immunity. However, their functional diversity and evolutionary conservation in ecologically crucial invertebrates, such as oysters, remain largely understudied. In this study, we identify and characterize a novel homolog of BPI/LBP, designated as ChBPI/LBP in the Hong Kong oyster (Crassostrea hongkongensis). Through structural and phylogenetic analysis, we identify ChBPI/LBP as a distinct member of the BPI protein family, with a high isoelectric point (pI of 9.26), indicating potent cationic BPI-like bactericidal function. We found that ChBPI/LBP is constitutively highly expressed at mucosal sites such as the gills and is rapidly upregulated in hemocytes following a challenge with Aeromonas hydrophila. Recombinant ChBPI/LBP demonstrated potent and specific bactericidal activity against Gram-negative pathogens. These findings suggest that ChBPI/LBP is an important antimicrobial peptide (AMP) effector in the oyster’s immune response. This work provides novel perspectives on the evolutionary mechanisms of innate immunity in bivalves and may have implications for disease management in aquaculture.