Fan Yang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Fan Yang has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Jianbo Wu
Department of Anesthesiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China
2 shared publications Shilei Cheng
Department of Anesthesiology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Anesthesia and Respiratory Critical Medicine, Shandong Provincial Clinical Research Center for Anesthesiology
2 shared publicationsGuanghan Wu
Department of Anesthesiology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Anesthesia and Respiratory Critical Medicine, Shandong Provincial Clinical Research Center for Anesthesiology
1 shared publicationJueheng Wu
Department of Anesthesiology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Anesthesia and Respiratory Critical Medicine, Shandong Provincial Clinical Research Center for Anesthesiology
1 shared publicationLanyun Xie
Department of Anesthesiology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Anesthesia and Respiratory Critical Medicine, Shandong Provincial Clinical Research Center for Anesthesiology, Jinan 250014, Shandong, China
1 shared publicationLiang Guo
Department of Anesthesiology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Anesthesia and Respiratory Critical Medicine, Shandong Provincial Clinical Research Center for Anesthesiology
1 shared publication
Latest Publications
- Open Access
- 18 June 2026
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 17, 1844850
Cross-talk among novel programmed cell death pathways: a decisive network in renal ischemia-reperfusion injury
Renal ischemia-reperfusion injury (IRI) is a major pathological driver of acute kidney injury (AKI), for which effective therapeutic strategies remain lacking. Recently, novel forms of programmed cell death (PCD), including pyroptosis, ferroptosis, cuproptosis and necroptosis, have been identified as key mediators of tubular damage and inflammation in renal IRI. This review delineates a hierarchically organized and spatiotemporally regulated PCD network, positioning it as a central determinant of cellular fate following renal IRI. We systematically characterize the distinct molecular signatures of each death modality and critically examine their extensive crosstalk within the pathological renal microenvironment. Synthesizing current evidence, we demonstrate that this network operates in a cell type- and phase-specific manner, driving a vicious cycle of inflammation and oxidative stress. Targeting this interconnected network rather than isolated pathways represents a paradigm shift. We critically assess current therapeutic strategies and their limitations in the context of this network. Finally, we propose a forward-looking roadmap that emphasizes combination therapies guided by spatial transcriptomics, patient stratification using PCD-specific biomarkers and the development of smart nanosystems capable of dynamically modulating key network nodes. Deciphering and therapeutically intervening in this PCD network is pivotal for developing effective treatments for renal IRI.
- 18 June 2026
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 17, 1844850
Open AccessCross-talk among novel programmed cell death pathways: a decisive network in renal ischemia-reperfusion injury
Renal ischemia-reperfusion injury (IRI) is a major pathological driver of acute kidney injury (AKI), for which effective therapeutic strategies remain lacking. Recently, novel forms of programmed cell death (PCD), including pyroptosis, ferroptosis, cuproptosis and necroptosis, have been identified as key mediators of tubular damage and inflammation in renal IRI. This review delineates a hierarchically organized and spatiotemporally regulated PCD network, positioning it as a central determinant of cellular fate following renal IRI. We systematically characterize the distinct molecular signatures of each death modality and critically examine their extensive crosstalk within the pathological renal microenvironment. Synthesizing current evidence, we demonstrate that this network operates in a cell type- and phase-specific manner, driving a vicious cycle of inflammation and oxidative stress. Targeting this interconnected network rather than isolated pathways represents a paradigm shift. We critically assess current therapeutic strategies and their limitations in the context of this network. Finally, we propose a forward-looking roadmap that emphasizes combination therapies guided by spatial transcriptomics, patient stratification using PCD-specific biomarkers and the development of smart nanosystems capable of dynamically modulating key network nodes. Deciphering and therapeutically intervening in this PCD network is pivotal for developing effective treatments for renal IRI.
- Top Cited Papers
- 31 January 2026
- Published by Elsevier in International Immunopharmacology
- Vol. 173, 116294
Lipid metabolism: a molecular switch to control inflammation
- 31 January 2026
- Published by Elsevier in International Immunopharmacology
- Vol. 173, 116294
Top Cited PapersLipid metabolism: a molecular switch to control inflammation