Franziska Hinterdobler
Franziska Hinterdobler has a total of 10 co-authors. Here are the top co-authors by number of shared publications:
- Dominik John
Research Group Biomedical Imaging Physics, Department of Physics, TUM School of Natural Sciences, and Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany
1 shared publication - Gregor Breitenhuber1 shared publication
- Jens Lucht
Georg-August-Universität Göttingen, Institut für Röntgenphysik, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany
1 shared publication Julia Herzen
1 shared publicationLuka Gaetani
1 shared publication- Marina Eckermann
Institut für Röntgenphysik, Universität Göttingen
1 shared publication
Latest Publications
- 5 February 2026
- Published by Optica Publishing Group in Optica
- Vol. 13 (2) , 273
Near-perfect efficiency in X-ray phase microtomography
X-ray microtomography at synchrotron sources is fundamentally limited by the high radiation dose applied to the samples, which restricts investigations to non-native tissue states and thereby compromises the biological relevance of the resulting data. The limitation stems from inefficient indirect detection schemes that require prolonged exposures. Efforts to extract additional contrast through multi-modal techniques, like modulation-based imaging, worsen the problem by requiring multiple tomographic scans. In addition, the techniques suffer from low modulator pattern visibility, which reduces measurement efficiency and sensitivity. We address both the detection efficiency and modulation visibility challenges using a setup that combines an X-ray waveguide, a structured phase modulator, and a photon-counting detector. Our approach simultaneously achieves near-theoretical limits in both visibility (95%) and quantum efficiency (98%), thereby enabling dose-efficient multi-modal microtomography at single-micrometer resolution. This advance represents an important step toward routine multi-modal microtomography of native-state biological specimens with the potential to advance biomedical research and disease diagnosis.
- 5 February 2026
- Published by Optica Publishing Group in Optica
- Vol. 13 (2) , 273
Near-perfect efficiency in X-ray phase microtomography
X-ray microtomography at synchrotron sources is fundamentally limited by the high radiation dose applied to the samples, which restricts investigations to non-native tissue states and thereby compromises the biological relevance of the resulting data. The limitation stems from inefficient indirect detection schemes that require prolonged exposures. Efforts to extract additional contrast through multi-modal techniques, like modulation-based imaging, worsen the problem by requiring multiple tomographic scans. In addition, the techniques suffer from low modulator pattern visibility, which reduces measurement efficiency and sensitivity. We address both the detection efficiency and modulation visibility challenges using a setup that combines an X-ray waveguide, a structured phase modulator, and a photon-counting detector. Our approach simultaneously achieves near-theoretical limits in both visibility (95%) and quantum efficiency (98%), thereby enabling dose-efficient multi-modal microtomography at single-micrometer resolution. This advance represents an important step toward routine multi-modal microtomography of native-state biological specimens with the potential to advance biomedical research and disease diagnosis.