Nicolas M Berbenetz
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Nicolas M Berbenetz has a total of 17 co-authors. Here are the top co-authors by number of shared publications:
- Alper Aydin
Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
1 shared publication - Andres Klein
Division of Cardiology, Department of Medicine, University of Ottawa and University of Ottawa Heart Institute , H-1285D, 40 Ruskin St. Ottawa, Ottawa Ontario K1Y 4W7
1 shared publication - Andrew D. Krahn
Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
1 shared publication - Calum Redpath
Division of Cardiology, Department of Medicine, University of Ottawa and University of Ottawa Heart Institute , H-1285D, 40 Ruskin St. Ottawa, Ottawa Ontario K1Y 4W7
1 shared publication - Darryl Raymond Davis
Division of Cardiology, Department of Medicine, University of Ottawa and University of Ottawa Heart Institute , H-1285D, 40 Ruskin St. Ottawa, Ottawa Ontario K1Y 4W7
1 shared publication - David Hugh Birnie
University of Ottawa Heart Institute, Ottawa, Ontario, Canada
1 shared publication
Latest Publications
- Open Access
- 29 January 2026
- Published by Oxford University Press (OUP) in EP Europace
- Vol. 28 (2)
Validation of the PADIT (prevention of arrhythmia device infection trial) risk score for infection and infection subtypes
Aims: Cardiac implantable electronic device (CIED) infection carries a substantial burden of morbidity, mortality, and cost. The Prevention of Arrhythmia Device Infection Trial (PADIT) risk score improves identification of high-risk patients and may guide targeted strategies to reduce infection. Recent work has categorized CIED infection into localized pocket vs. systemic infection, with early reports suggesting different risk factors for each. However, no current risk score has been validated for infection subtypes. ObjectivesIndependently validate the PADIT infection risk score.Compare risk factors for infection subtypes.Assess PADIT performance in predicting subtype-specific infection. Methods and results: A prospective registry was initiated at the University of Ottawa Heart Institute in 2007 to capture all CIED procedures and prospectively identify infections in collaboration with the infection prevention team. PADIT risk score components were documented for each procedure. All suspected infections were adjudicated independently by two physicians (with a third if required), blinded to PADIT score and baseline variables, and subclassified as pocket or systemic infection. Logistic regression models were generated to validate PADIT performance for each subtype, with evaluation using Akaike and Bayesian information criteria (AIC/BIC), C-statistics, and calibration slope. Between 2007 and 2020, 14,225 procedures were performed (mean age 72 ± 14 years, 35% female, 70% new implants, 18% generator changes, 11% upgrades). A total of 103 infections (0.73%) were adjudicated, of which 71 (69%) were pocket and 32 (31%) systemic. The PADIT score showed good predictive performance with a C-statistic of 0.687 (95% CI 0.655–0.743), similar to the derivation cohort (0.702, 95% CI 0.661–0.741). Notably, the number of prior procedures was strongly associated with pocket infection but not systemic infection. PADIT discrimination was consistent across subtypes: pocket infection C-statistic 0.691 (95% CI 0.649–0.761) and systemic infection 0.746 (95% CI 0.707–0.848). Calibration slopes demonstrated good agreement between predicted and observed events, with the best fit for systemic infection. Conclusion: The PADIT score was independently validated with discrimination and calibration similar to the original derivation cohort. Importantly, prior procedures predicted pocket but not systemic infection. Overall, PADIT performed well in predicting both subtypes, with the strongest model fit observed for systemic infection.
- 29 January 2026
- Published by Oxford University Press (OUP) in EP Europace
- Vol. 28 (2)
Open AccessValidation of the PADIT (prevention of arrhythmia device infection trial) risk score for infection and infection subtypes
Aims: Cardiac implantable electronic device (CIED) infection carries a substantial burden of morbidity, mortality, and cost. The Prevention of Arrhythmia Device Infection Trial (PADIT) risk score improves identification of high-risk patients and may guide targeted strategies to reduce infection. Recent work has categorized CIED infection into localized pocket vs. systemic infection, with early reports suggesting different risk factors for each. However, no current risk score has been validated for infection subtypes. ObjectivesIndependently validate the PADIT infection risk score.Compare risk factors for infection subtypes.Assess PADIT performance in predicting subtype-specific infection. Methods and results: A prospective registry was initiated at the University of Ottawa Heart Institute in 2007 to capture all CIED procedures and prospectively identify infections in collaboration with the infection prevention team. PADIT risk score components were documented for each procedure. All suspected infections were adjudicated independently by two physicians (with a third if required), blinded to PADIT score and baseline variables, and subclassified as pocket or systemic infection. Logistic regression models were generated to validate PADIT performance for each subtype, with evaluation using Akaike and Bayesian information criteria (AIC/BIC), C-statistics, and calibration slope. Between 2007 and 2020, 14,225 procedures were performed (mean age 72 ± 14 years, 35% female, 70% new implants, 18% generator changes, 11% upgrades). A total of 103 infections (0.73%) were adjudicated, of which 71 (69%) were pocket and 32 (31%) systemic. The PADIT score showed good predictive performance with a C-statistic of 0.687 (95% CI 0.655–0.743), similar to the derivation cohort (0.702, 95% CI 0.661–0.741). Notably, the number of prior procedures was strongly associated with pocket infection but not systemic infection. PADIT discrimination was consistent across subtypes: pocket infection C-statistic 0.691 (95% CI 0.649–0.761) and systemic infection 0.746 (95% CI 0.707–0.848). Calibration slopes demonstrated good agreement between predicted and observed events, with the best fit for systemic infection. Conclusion: The PADIT score was independently validated with discrimination and calibration similar to the original derivation cohort. Importantly, prior procedures predicted pocket but not systemic infection. Overall, PADIT performed well in predicting both subtypes, with the strongest model fit observed for systemic infection.