Elizabeth S. Bennett
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Elizabeth S. Bennett has a total of 16 co-authors. Here are the top co-authors by number of shared publications:
- Anne F. Peery
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina
1 shared publication - Brigitte Allard
UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
1 shared publication - Caroline Baker
Department of Medicine
1 shared publication - Cory H. White
The Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine University of Southampton
1 shared publication - Cynthia L. Gay
Division of Infectious Diseases, University of North Carolina School of Medicine , Chapel Hill, North Carolina
1 shared publication - David M. Margolis
Department of Medicine, UNC Chapel Hill, Chapel Hill, NC
1 shared publication
Latest Publications
- Open Access
- 23 December 2025
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 136 (4)
Single-cell characterization of the gastrointestinal HIV reservoir reveals heterogeneous cellular phenotypes
Human gastrointestinal (GI) tissues are a major site of HIV-1 viral persistence, but the nature of the GI reservoir remains poorly described. To characterize the GI HIV reservoir, we profiled cells from GI tissue and matched PBMCs from 10 people with HIV on antiretroviral therapy using single-cell RNA sequencing. We identified distinct compartment-specific patterns of gene expression, highlighting key differences between blood and colon CD4 + T cell populations. vRNA + cells from both blood and GI tissue were heterogeneous and found in multiple subtypes of CD4 + T cells, although vRNA + cells were particularly enriched in cells with Th17 or Treg17 phenotypes. Transcriptomic comparison of HIV vRNA + and vRNA – T cells revealed 116 differentially expressed genes that were associated with HIV infection, including ZBED2 , MAF , and IL17F . These data provide what we believe to be new information regarding the GI-resident HIV reservoir and suggest that compartment-specific patterns of gene expression are associated with HIV infection.
- 23 December 2025
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 136 (4)
Open AccessSingle-cell characterization of the gastrointestinal HIV reservoir reveals heterogeneous cellular phenotypes
Human gastrointestinal (GI) tissues are a major site of HIV-1 viral persistence, but the nature of the GI reservoir remains poorly described. To characterize the GI HIV reservoir, we profiled cells from GI tissue and matched PBMCs from 10 people with HIV on antiretroviral therapy using single-cell RNA sequencing. We identified distinct compartment-specific patterns of gene expression, highlighting key differences between blood and colon CD4 + T cell populations. vRNA + cells from both blood and GI tissue were heterogeneous and found in multiple subtypes of CD4 + T cells, although vRNA + cells were particularly enriched in cells with Th17 or Treg17 phenotypes. Transcriptomic comparison of HIV vRNA + and vRNA – T cells revealed 116 differentially expressed genes that were associated with HIV infection, including ZBED2 , MAF , and IL17F . These data provide what we believe to be new information regarding the GI-resident HIV reservoir and suggest that compartment-specific patterns of gene expression are associated with HIV infection.