Laura Blanca-Pariente
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Laura Blanca-Pariente has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Alejandra Pera
Molecular Immunology CTS-208 Group, Cell Biology, Physiology and Immunology Department, University of Córdoba, 14004 Córdoba, Spain
1 shared publication - Alexander Batista-Duharte
Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil
1 shared publication - Irene Reina-Alfonso
Immunology and Allergy Group (GC01), Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Av. Menendez Pidal s/n, 14004 Cordoba, Spain
1 shared publication - Isabel María Vallejo-Bermúdez
Immunology and Allergy Group (GC01), Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Av. Menendez Pidal s/n, 14004 Cordoba, Spain
1 shared publication - Mabel Rocio Miranda-Echagüe
Fondazione Biotecnopolo di Siena, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
1 shared publication - Silvia Fernández
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Av. Menendez Pidal s/n, 14004 Cordoba, Spain
1 shared publication
Latest Publications
- Open Access
CD57-Expressing Lymphocytes: From Chronic Viral Response to Age-Related Inflammation
CD57-expressing lymphocytes constitute a distinct subset of immune cells with enhanced cytotoxic and pro-inflammatory functions. Initially described in the context of chronic viral infections, most notably cytomegalovirus (CMV), these cells are now recognized as central contributors to immunosenescence and age-related immune dysregulation. Their progressive accumulation reflects prolonged antigenic exposure and sustained immune activation, thereby linking persistent viral infections with long-term disruptions of immune homeostasis. Emerging evidence indicates that CD57 expression denotes a state of terminal differentiation in both T and natural killer (NK) cell compartments, and is associated with cytotoxicity, altered cytokine secretion, and a pro-inflammatory phenotype. This review summarizes the phenotypic and functional characteristics of CD57+ lymphocytes, examines their association with CMV and other chronic viral infections, and explores their potential role in ageing and age-related diseases. Elucidating the biology of CD57+ lymphocytes in the context of chronic viral infections may provide novel insights into immune ageing and help identify potential targets for therapeutic strategies aimed at restoring immune balance in older adults.
Open AccessCD57-Expressing Lymphocytes: From Chronic Viral Response to Age-Related Inflammation
CD57-expressing lymphocytes constitute a distinct subset of immune cells with enhanced cytotoxic and pro-inflammatory functions. Initially described in the context of chronic viral infections, most notably cytomegalovirus (CMV), these cells are now recognized as central contributors to immunosenescence and age-related immune dysregulation. Their progressive accumulation reflects prolonged antigenic exposure and sustained immune activation, thereby linking persistent viral infections with long-term disruptions of immune homeostasis. Emerging evidence indicates that CD57 expression denotes a state of terminal differentiation in both T and natural killer (NK) cell compartments, and is associated with cytotoxicity, altered cytokine secretion, and a pro-inflammatory phenotype. This review summarizes the phenotypic and functional characteristics of CD57+ lymphocytes, examines their association with CMV and other chronic viral infections, and explores their potential role in ageing and age-related diseases. Elucidating the biology of CD57+ lymphocytes in the context of chronic viral infections may provide novel insights into immune ageing and help identify potential targets for therapeutic strategies aimed at restoring immune balance in older adults.