Die Hu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Die Hu has a total of 21 co-authors. Here are the top co-authors by number of shared publications:
Can Zhao
State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Disease, School of Ophthalmology, Shandong First Medical University, Qingdao, China
2 shared publicationsChong Wang
State Key Laboratory of Mariculture Biobreeding and Sustainable Goods; Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture; Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity; Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China
2 shared publications- Danielle E. Anderson
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
2 shared publications Hai Zhu
Department of Urology, Qingdao Municipal Hospital, Qingdao, China
2 shared publications- Jia Yin
Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China
2 shared publications Jitao Xia
State Key Laboratory of Mariculture Biobreeding and Sustainable Goods; Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture; Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity; Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China
2 shared publications
Latest Publications
- 5 May 2026
- Published by Springer Nature in Nature Microbiology
- Vol. 11 (6) , 1756
Author Correction: An emerging human eye disease is associated with aquatic virus zoonotic infection
- 5 May 2026
- Published by Springer Nature in Nature Microbiology
- Vol. 11 (6) , 1756
Author Correction: An emerging human eye disease is associated with aquatic virus zoonotic infection
- Top Cited Papers
- 26 March 2026
- Published by Springer Nature in Nature Microbiology
- Vol. 11 (4) , 892-906
An emerging human eye disease is associated with aquatic virus zoonotic infection
Climate change and human activities have increased the risk of virus spillover from wildlife, posing a threat to human health. A human ocular disease called persistent ocular hypertensive viral anterior uveitis (POH-VAU) has recently emerged; however, the cause is unclear. Here we report that POH-VAU is associated with covert mortality nodavirus (CMNV) of aquatic origin. CMNV is prevalent in farmed and wild aquatic animals worldwide. We confirmed CMNV infection in ocular tissues and seroconversion in 70 patients with POH-VAU. An exposure survey and analysis of logistic regression models revealed that CMNV exposure frequency, number of severe exposures and exposure severity were associated with an increased risk of POH-VAU. Epidemiological data indicate that frequent unprotected processing of aquatic animals and consumption of raw aquatic animals were commonly reported exposure events, collectively accounting for 71.4% of investigated cases. Challenge tests revealed that CMNV can cause elevated intraocular pressure and pathological damage to ocular tissues in mice and can infect mammalian cells in vitro. This study reveals that an aquatic animal virus is associated with an emerging human disease.
- 26 March 2026
- Published by Springer Nature in Nature Microbiology
- Vol. 11 (4) , 892-906
Top Cited PapersAn emerging human eye disease is associated with aquatic virus zoonotic infection
Climate change and human activities have increased the risk of virus spillover from wildlife, posing a threat to human health. A human ocular disease called persistent ocular hypertensive viral anterior uveitis (POH-VAU) has recently emerged; however, the cause is unclear. Here we report that POH-VAU is associated with covert mortality nodavirus (CMNV) of aquatic origin. CMNV is prevalent in farmed and wild aquatic animals worldwide. We confirmed CMNV infection in ocular tissues and seroconversion in 70 patients with POH-VAU. An exposure survey and analysis of logistic regression models revealed that CMNV exposure frequency, number of severe exposures and exposure severity were associated with an increased risk of POH-VAU. Epidemiological data indicate that frequent unprotected processing of aquatic animals and consumption of raw aquatic animals were commonly reported exposure events, collectively accounting for 71.4% of investigated cases. Challenge tests revealed that CMNV can cause elevated intraocular pressure and pathological damage to ocular tissues in mice and can infect mammalian cells in vitro. This study reveals that an aquatic animal virus is associated with an emerging human disease.