Vikram Godishala
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Vikram Godishala has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Aditya Velidandi
Department of Basic Sciences, School of Sciences and Humanities, SR University, Warangal, India
1 shared publication - Himabindu Kurra
Department of Biotechnology, Vaagdevi Degree and P.G. College, Warangal 506001, India
1 shared publication - Pradeep Kumar Gandam
Department of Biotechnology, National Institute of Technology, Warangal 506004, India
1 shared publication - Saideep Mallepaka
Department of Biotechnology, Bharatiya Engineering Science and Technology Innovation University, Gorantla Mandal 506001, India
1 shared publication - Swati Dahariya
Department of Biotechnology, National Institute of Technology, Warangal 506004, Telangana, India
1 shared publication
Latest Publications
- Open Access
Green Synthesis of Gold Nanoparticles Using Kalanchoe pinnata Leaf Extract: One-Factor Screening and Multivariable Optimization of Surface Plasmon Resonance Responses
This study presents a statistically optimized protocol for the green synthesis of gold nanoparticles (Au NPs) using aqueous Kalanchoe pinnata leaf extract (AKPLE). An integrated experimental strategy, transitioning from preliminary one-factor-at-a-time (OFAT) screening to a five-factor Box–Behnken Design, was employed to model and simultaneously optimize two critical optical responses derived from surface plasmon resonance: the peak position (λmax) and its absorbance intensity. Highly predictive quadratic models (R2 > 0.97) revealed that synthesis outcomes are governed by significant nonlinear curvature, with minimal interaction effects. Multi-response optimization via a desirability function identified a harmonized set of conditions (HAuCl4: 0.44 mM, AKPLE: 3.50% v/v, temperature: 80.6 °C, pH: 7.2, time: 66.7 min) predicted to minimize λmax at 540 nm while maximizing absorbance to 0.61. Synthesis under these optimized conditions successfully produced spherical, crystalline Au NPs, as confirmed by characterization (average TEM size: 26.3 ± 4.1 nm; zeta potential: –30.45 mV). This work demonstrates that a hybrid OFAT-RSM approach is superior for the precise, multivariate optimization of plant-mediated Au NP synthesis, providing a validated and scalable framework to balance nanoparticle size and plasmonic intensity—an outcome unattainable through conventional OFAT methods.
Open AccessGreen Synthesis of Gold Nanoparticles Using Kalanchoe pinnata Leaf Extract: One-Factor Screening and Multivariable Optimization of Surface Plasmon Resonance Responses
This study presents a statistically optimized protocol for the green synthesis of gold nanoparticles (Au NPs) using aqueous Kalanchoe pinnata leaf extract (AKPLE). An integrated experimental strategy, transitioning from preliminary one-factor-at-a-time (OFAT) screening to a five-factor Box–Behnken Design, was employed to model and simultaneously optimize two critical optical responses derived from surface plasmon resonance: the peak position (λmax) and its absorbance intensity. Highly predictive quadratic models (R2 > 0.97) revealed that synthesis outcomes are governed by significant nonlinear curvature, with minimal interaction effects. Multi-response optimization via a desirability function identified a harmonized set of conditions (HAuCl4: 0.44 mM, AKPLE: 3.50% v/v, temperature: 80.6 °C, pH: 7.2, time: 66.7 min) predicted to minimize λmax at 540 nm while maximizing absorbance to 0.61. Synthesis under these optimized conditions successfully produced spherical, crystalline Au NPs, as confirmed by characterization (average TEM size: 26.3 ± 4.1 nm; zeta potential: –30.45 mV). This work demonstrates that a hybrid OFAT-RSM approach is superior for the precise, multivariate optimization of plant-mediated Au NP synthesis, providing a validated and scalable framework to balance nanoparticle size and plasmonic intensity—an outcome unattainable through conventional OFAT methods.