Yongliang Wang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Yongliang Wang has a total of 13 co-authors. Here are the top co-authors by number of shared publications:
Xiaojun Liu
Shandong Key Laboratory of Neurorehabilitation, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266071, China; NHC Key Laboratory of Cardiopulmonary Rehabilitation and Functional Recovery (University of Health and Rehabilitation Sciences), College of Life Science and Health, University of Health and Rehabilitation Sciences, Qingdao, 266024, China
2 shared publicationsAimei Liu
School of Life Sciences and Health University of Health and Rehabilitation Sciences Qingdao Shandong PR China
1 shared publicationChao Li
Shandong Key Laboratory of Neurorehabilitation, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266071, China; NHC Key Laboratory of Cardiopulmonary Rehabilitation and Functional Recovery (University of Health and Rehabilitation Sciences), College of Life Science and Health, University of Health and Rehabilitation Sciences, Qingdao, 266024, China
1 shared publicationFeng Shao
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering Ocean University of China Qingdao PR China
1 shared publication- Guixue Wang
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China
1 shared publication Jiangtao Li
School of Life Sciences and Health University of Health and Rehabilitation Sciences Qingdao Shandong PR China
1 shared publication
Latest Publications
- 25 August 2026
- Published by Elsevier in International Journal of Biological Macromolecules
- Vol. 381 (Pt 1) , 154182
Molecular weight-dependent cellular distribution and immunoreactivity mechanisms of hyaluronic acid
- 25 August 2026
- Published by Elsevier in International Journal of Biological Macromolecules
- Vol. 381 (Pt 1) , 154182
Molecular weight-dependent cellular distribution and immunoreactivity mechanisms of hyaluronic acid
- Open Access
- 9 April 2026
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1558 (1) , e70247
Detection of Mesenchymal Stem Cell Aging Using an Integrin Mechano‐Probe
Mesenchymal stem cells (MSCs) play a crucial role in cell therapy, but their efficacy diminishes with age. While biochemical methods like flow cytometry, immunoblotting, β‐galactosidase labeling, and gene profiling are effective for screening MSC aging, mechanical factors also change with aging. After analyzing the transcriptomes of young and aged MSCs, we observed downregulation of adhesion‐related genes and, based on those data, developed an integrin mechano‐probe to measure integrin forces in MSCs. The probe's effectiveness was validated by mapping integrin forces in young and aged MSCs, revealing reduced integrin force signals in aged cells that correlated with downregulated expression of β1 integrins. This finding was further confirmed by flow cytometry and β‐galactosidase staining. Overexpression of integrin β1 in aged MSCs restored mechanical signaling and increased p‐ERK production, suggesting that the integrin β1/ERK pathway plays a role in rescuing the contractility of aged MSCs. Our mechano‐probe enables distinguishing aged MSCs in a mixed pool of young and aged MSCs and identifying aged MSCs taken from mouse tissue. Integrin tension signals, as measured by a mechano‐probe, may thus complement biochemical markers in assessing MSC aging.
- 9 April 2026
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1558 (1) , e70247
Open AccessDetection of Mesenchymal Stem Cell Aging Using an Integrin Mechano‐Probe
Mesenchymal stem cells (MSCs) play a crucial role in cell therapy, but their efficacy diminishes with age. While biochemical methods like flow cytometry, immunoblotting, β‐galactosidase labeling, and gene profiling are effective for screening MSC aging, mechanical factors also change with aging. After analyzing the transcriptomes of young and aged MSCs, we observed downregulation of adhesion‐related genes and, based on those data, developed an integrin mechano‐probe to measure integrin forces in MSCs. The probe's effectiveness was validated by mapping integrin forces in young and aged MSCs, revealing reduced integrin force signals in aged cells that correlated with downregulated expression of β1 integrins. This finding was further confirmed by flow cytometry and β‐galactosidase staining. Overexpression of integrin β1 in aged MSCs restored mechanical signaling and increased p‐ERK production, suggesting that the integrin β1/ERK pathway plays a role in rescuing the contractility of aged MSCs. Our mechano‐probe enables distinguishing aged MSCs in a mixed pool of young and aged MSCs and identifying aged MSCs taken from mouse tissue. Integrin tension signals, as measured by a mechano‐probe, may thus complement biochemical markers in assessing MSC aging.