Ahmet Umit Sahin
Ahmet Umit Sahin has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
Adnan Corum
1 shared publication- Aylar Feizollahi Vahid
Zonguldak Bülent Ecevit Üniversitesi
1 shared publication - Beyza Sarikavak-Lisesivdin
Gazi University
1 shared publication Erdi Bulus
1 shared publicationGulseren Sakarya
1 shared publication- Okan Sar
Radiation Oncology Department, Hacettepe University, Ankara 06230, Türkiye
1 shared publication
Latest Publications
- Open Access
- 29 July 2026
- Published by Elsevier in SSRN Electronic Journal
Radiation-Induced Structure-Duct Decomposition in Electrospun PVA Nanostrips for Rapid Intraoral Drug Delivery in Deep Space Missions
Long-duration space missions impair oral drug bioavailability due to gastrointestinal dysfunction and expose formulations to cumulative ionizing radiation (0.5–1000+ Gy). Here, a poly(vinyl alcohol) (PVA)-based orodispersible nanostrip (ODNS) containing vitamin C, Spirulina platensis, and Lamium galeobdolon extract was developed for ultrafast buccal delivery. Electrospun nanofibers were evaluated unirradiated, after low-dose X-ray (100 mGy), and after high-dose gamma (1000 Gy). FTIR confirmed physical hydrogen bonding of all bioactives without covalent degradation, even at 1000 Gy. Surprisingly, gamma-irradiated quaternary formulations (F8) exhibited 156.7% elongation at break despite severe morphological collapse (FEGSEM), surpassing pure PVA (124.5%) and unirradiated F4 (90.5%). This unprecedented ductility is attributed to radiation-induced cross-linking (DSC: crystallinity increased from 29.0% to 31.4%, *p* < 0.05), creating a deformable molecular network. Spirulina-containing formulations showed superior radiotolerance, preserving fibrous architecture below 1000 Gy via phycocyanin-mediated ROS scavenging. Release kinetics were composition-dependent and biphasic: optimal formulation (F12, 100 mGy) achieved 44% release in 1 min, 83% in 3 min, and 95% in 5 min, meeting emergency feeding targets. TGA revealed increased char residue (17.6% at 800°C) due to bioactive thermal barrier effects. This work presents the first radiation-resistant nanostrip platform for direct intraoral absorption, bypassing gastrointestinal limitations for astronaut health in deep space missions.
- 29 July 2026
- Published by Elsevier in SSRN Electronic Journal
Open AccessRadiation-Induced Structure-Duct Decomposition in Electrospun PVA Nanostrips for Rapid Intraoral Drug Delivery in Deep Space Missions
Long-duration space missions impair oral drug bioavailability due to gastrointestinal dysfunction and expose formulations to cumulative ionizing radiation (0.5–1000+ Gy). Here, a poly(vinyl alcohol) (PVA)-based orodispersible nanostrip (ODNS) containing vitamin C, Spirulina platensis, and Lamium galeobdolon extract was developed for ultrafast buccal delivery. Electrospun nanofibers were evaluated unirradiated, after low-dose X-ray (100 mGy), and after high-dose gamma (1000 Gy). FTIR confirmed physical hydrogen bonding of all bioactives without covalent degradation, even at 1000 Gy. Surprisingly, gamma-irradiated quaternary formulations (F8) exhibited 156.7% elongation at break despite severe morphological collapse (FEGSEM), surpassing pure PVA (124.5%) and unirradiated F4 (90.5%). This unprecedented ductility is attributed to radiation-induced cross-linking (DSC: crystallinity increased from 29.0% to 31.4%, *p* < 0.05), creating a deformable molecular network. Spirulina-containing formulations showed superior radiotolerance, preserving fibrous architecture below 1000 Gy via phycocyanin-mediated ROS scavenging. Release kinetics were composition-dependent and biphasic: optimal formulation (F12, 100 mGy) achieved 44% release in 1 min, 83% in 3 min, and 95% in 5 min, meeting emergency feeding targets. TGA revealed increased char residue (17.6% at 800°C) due to bioactive thermal barrier effects. This work presents the first radiation-resistant nanostrip platform for direct intraoral absorption, bypassing gastrointestinal limitations for astronaut health in deep space missions.